Parathyroid hormone monitoring during total parathyroidectomy for renal hyperparathyroidism: pilot study of the impact of renal function and assay specificity

Clinical Chemistry
Christian BieglmayerBruno Niederle

Abstract

Commonly used assays for intact parathyroid hormone (iPTH) detect not only the biologically active 84-amino acid hormone [PTH1-84], but cross-react with an N-terminal-truncated fragment. Because iPTH assays often fail to predict success of parathyroidectomy in patients with renal hyperparathyroidism (rHPT), we compared results of a 3rd-generation PTH1-84 assay (Bio-iPTH; Nichols Institute Diagnostics) with two 2nd-generation iPTH assays (from Nichols and Roche Diagnostics) by evaluating the PTH clearance kinetics during surgical treatment. We collected blood samples in short time intervals from 35 consecutive surgical patients with rHPT. Three patients had to be excluded from further calculations; the remainder were grouped according to kidney function and postoperative outcome. All samples were analyzed with the 3 automated PTH assays, which have different specificities. Twenty minutes after removal of the last gland, the PTH1-84 values decreased to within the reference intervals in all patients with total and subtotal resection; however, iPTH concentrations normalized in only one half of these patients. In patients with poor renal function, the half-life of PTH1-84 was shorter than the half-lives obtained with the iPTH assays...Continue Reading

References

Jan 5, 1978·The New England Journal of Medicine·J FreitagE Slatopolsky
Dec 11, 1988·The American Journal of Physiology·F R BringhurstJ T Potts
Nov 14, 1998·The Journal of Clinical Endocrinology and Metabolism·G W MaierH D Becker
Apr 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GaoT L Cantor
Sep 25, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·William G GoodmanHarald Jüppner
Jan 23, 2003·Journal of the American Society of Nephrology : JASN·Claus P SchmittFranz Schaefer
Feb 1, 2003·Clinical Chemistry·Alan H TerryA Wayne Meikle

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Citations

Apr 14, 2010·World Journal of Surgery·Susan C PittRebecca S Sippel
Nov 22, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Catherine MadorinAlfio Ferlito
Apr 28, 2009·Langenbeck's Archives of Surgery·Philipp RissBruno Niederle
Nov 13, 2012·Langenbeck's Archives of Surgery·Philipp RissBruno Niederle
Feb 3, 2016·Biotechnology Advances·Brian M CumminsGlenn M Walker
Oct 20, 2009·The Surgical Clinics of North America·Susan C PittHerbert Chen
May 12, 2007·Clinical Biochemistry·David E C ColePak-Cheung Chan
Sep 25, 2007·The Laryngoscope·Kelly A LoftusDavid J Terris
Jun 27, 2008·Annals of Surgery·Frédéric TriponezPieter Evenepoel
Feb 28, 2019·Drugs·Rowena Delos SantosThin Thin Maw
May 26, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Clare GardhamEdmund J Lamb
Mar 1, 2011·Expert Review of Endocrinology & Metabolism·Haggi Mazeh, Herbert Chen
Dec 7, 2018·Langenbeck's Archives of Surgery·Thomas BurgstallerPhilipp Riss
Jan 24, 2018·Critical Reviews in Clinical Laboratory Sciences·Li-Sheng Chen, Ravinder J Singh
Apr 8, 2020·International Journal of Endocrinology·Marie-Hélène Gannagé-YaredGhassan Sleilaty
Jan 22, 2021·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Andre Albuquerque SilveiraFabio Luiz de Menezes Montenegro

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