PMID: 18411112Jan 1, 1990Paper

Parathyroid hormone-receptor interactions

Trends in Endocrinology and Metabolism : TEM
M P Caulfield, M Rosenblatt

Abstract

Identification of sites within the antagonist peptide of parathyroid hormone (PTH) that are "tolerant" of a wide range of amino acid substitutions has led to the design of new PTH antagonists. These antagonists have increased potency because of substitution, at appropriate sites, of amino acids that increase the interaction of the ligand with its receptor but do not cause signal transduction. Similar modifications in the parathyroid hormone-related protein (PTHrP) antagonist led to antagonists with increased potency. Further, the partial agonism of this analog could be removed by exchange of residues between PTH and PTHrP.

References

Oct 16, 1986·The New England Journal of Medicine·M Rosenblatt
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M A ThiedeG A Rodan
Feb 1, 1988·The Journal of Clinical Investigation·A F StewartA E Broadus
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D D ThompsonG A Rodan
Jan 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J T PottsG D Aurbach
Jan 1, 1982·Advances in Protein Chemistry·J T PottsM Rosenblatt

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Citations

Oct 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M NakaiT Fujita
Nov 1, 1993·Peptides·S Harvey, S Hayer
Aug 1, 1991·Current Opinion in Biotechnology·V J Hruby, S D Sharma
Oct 16, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Mihaly VaszilkoPeter Lakatos
Dec 23, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Joseph D GardinierDavid H Kohn
Aug 3, 2005·Journal of Occupational Health Psychology·Marjan J Gorgievski-DuijvesteijnPeter G M van der Heijden
Aug 16, 1996·The Journal of Biological Chemistry·T J GardellaH Jüppner
Nov 24, 1999·The American Journal of Physiology·M MannstadtT J Gardella

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