Parathyroid hormone regulates the rat collagenase-3 promoter in osteoblastic cells through the cooperative interaction of the activator protein-1 site and the runt domain binding sequence.

The Journal of Biological Chemistry
N SelvamuruganN C Partridge

Abstract

Parathyroid hormone induces collagenase-3 gene transcription in rat osteoblastic cells. Here, we characterized the basal, parathyroid hormone regulatory regions of the rat collagenase-3 gene and the proteins involved in this regulation. The minimal parathyroid hormone-responsive region was observed to be between base pairs -38 and -148. Deleted and mutated constructs showed that the activator protein-1 and the runt domain binding sites are both required for basal expression and parathyroid hormone activation of this gene. The runt domain site is identical to an osteoblast-specific element-2 or acute myelogenous leukemia binding sequence in the mouse and rat osteocalcin genes, respectively. Overexpression of an acute myelogenous leukemia-1 repressor protein inhibited parathyroid hormone activation of the promoter, indicating a requirement of acute myelogenous leukemia-related factor(s) for this activity. Overexpression of c-Fos, c-Jun, osteoblast-specific factor-2, and core binding factor-beta increased the response to parathyroid hormone of the wild type (-148) promoter but not with mutation of either or both the activator protein-1 and runt domain binding sites. In summary, we conclude that there is a cooperative interaction o...Continue Reading

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Citations

Oct 21, 1999·Journal of Cellular Physiology·S K WinchesterN C Partridge
Sep 1, 2000·Journal of Cellular Biochemistry·N SelvamuruganN C Partridge
Apr 23, 2002·Journal of Cellular Biochemistry·Kannan ThirunavukkarasuJude E Onyia
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Oct 17, 2001·Developmental and Comparative Immunology·D R Barreda, M Belosevic
Jan 30, 2002·Gene·John T SwarthoutNicola C Partridge
Mar 27, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ching-Hao LiJaw-Jou Kang
Nov 25, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C FilantiP Manduca
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Feb 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M UchidaH Kawaguchi
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