PMID: 8948289Nov 1, 1996Paper

Parathyroid hormone-related peptide in synovial fluid and disease activity of rheumatoid arthritis

British Journal of Rheumatology
K OkanoS Yamashita

Abstract

To understand the clinical role of parathyroid hormone-related peptide (PTHrP) in rheumatoid arthritis (RA), we analysed the circulatory and synovial fluid (SF) concentrations of the N- and C-terminal regions of PTHrP (N- and C-PTHrP) in RA (n = 38), osteoarthritis (OA, n = 45) and control (n = 11) subjects. The SF level of C-PTHrP was markedly higher in RA compared with control and OA groups, while no differences in circulatory C-PTHrP were present among the three groups. In contrast, the SF level of N-PTHrP was marginally higher in OA patients. C-PTHrP levels in SF correlated significantly with CRP, ESR and SF IL-1 receptor antagonist. To identify the mechanism of elevated PTHrP levels in SF, immunohistochemistry and in situ hybridization of synovial membrane (SM) were performed in each subject. Overexpression of PTHrP was identified in the sublining cells within papillary proliferated SM of RA patients only. Our results indicate that C-PTHrP produced from SM into SF reflects the disease activity in RA.

Citations

Oct 3, 2002·Biochemical and Biophysical Research Communications·J L FunkW Carley
Jul 29, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·D Inoue, T Matsumoto
Oct 29, 2000·Annals of the Rheumatic Diseases·S R Goldring
May 16, 2002·Current Rheumatology Reports·Steven R Goldring, Ellen M Gravallese
Sep 21, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Nigel FoxEmma Woolliams
Nov 30, 2005·Immunological Reviews·Nicole C WalshEllen M Gravallese
Mar 10, 2010·Journal of Internal Medicine·R H StraubG Pongratz
May 9, 2015·Mediators of Inflammation·Piero RuscittiRoberto Giacomelli
May 16, 2018·Endocrine-related Cancer·Claudia Tulotta, Penelope Ottewell
Oct 19, 2000·Arthritis and Rheumatism·E M Gravallese, S R Goldring
Jul 16, 2002·Current Opinion in Rheumatology·Steven R Goldring

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