Parathyroid hormone-related protein: from hypercalcemia of malignancy to developmental regulatory molecule

The American Journal of the Medical Sciences
M E DunbarA E Broadus

Abstract

Parathyroid hormone-related protein (PTHrP) was originally discovered because of its role in humoral hypercalcemia of malignancy (HHM), a common metabolic complication of many types of cancer. In HHM, PTHrP is released into the circulation by malignant cells and cross reacts with parathyroid hormone (PTH) receptors in bone and kidney, which results in hypercalcemia. In recent years, it has become clear that PTHrP is a normal product of many adult and fetal tissues where it appears to act in an autocrine and/or paracrine fashion to regulate organogenesis. This article explores the molecular evolution of PTHrP and how this understanding has begun to shed some light on the molecular mechanisms responsible for the biochemical manifestations of HHM. In addition, the normal biological function of PTHrP is discussed, with an emphasis on its role as a developmental regulatory molecule.

References

Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M ManginD E Barton
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J M MoseleyJ D Zajac
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M ManginA E Broadus
Feb 1, 1988·The Journal of Clinical Investigation·A F StewartA E Broadus
Aug 1, 1982·The Journal of Clinical Endocrinology and Metabolism·A F StewartR Baron
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·J J WysolmerskiW M Philbrick
Jan 1, 1994·Annual Review of Medicine·J J Wysolmerski, A E Broadus
Jan 1, 1993·The Journal of Cell Biology·A van de StolpeL H Defize

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Citations

Jan 24, 2012·Nature Genetics·Maya GhoussainiDouglas F Easton
Mar 29, 2013·Nature Genetics·Kyriaki MichailidouDouglas F Easton
Dec 14, 2001·Surgery·B K Kinder
May 19, 1998·Pediatric Research·M V SpezialeL J Deftos
May 27, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lewis P RubinHenry M Kronenberg

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