Abstract
Parathyroid hormone-related protein (PTHrP) was first identified as a pathogenetic factor for the hypercalcemia of malignancy. Recently PTHrP is focused as a physiological paracrine factor regulating cell proliferation and differentiation in many tissues during fetal and postnatal growth. Evidence for the skeletal origin of PTHrP comes from several sources and targeted disruption of the PTHrP gene in mice has resulted in a phenotype with accelerated endochondral bone formation, suggesting PTHrP as a factor regulating chondrocyte differentiation. Indian hedgehog, one of the conserved family of hedgehog regulating segmentation of Drosophila, is found to be an upstream factor of PTHrP in a regulating pathway of chondrocyte differentiation. Moreover, Bcl-2, a protein that controls programmed cell death in several cell types, is suggested to lie downstream of PTHrP in this pathway. A point mutation of PTH/PTHrP receptor is identified in a patient with Jansen-type metaphyseal chondrodysplasia and constitutive, ligand independent activation is indicated in this mutant receptor.
References
Nov 25, 1991·Science·H JüppnerH M Kronenberg
Sep 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R L ShewD L McNeill
Sep 1, 1991·The Journal of Clinical Endocrinology and Metabolism·J M MoseleyM A Horton
Jun 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L L MokC W Cooper
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J M MoseleyJ D Zajac
Sep 29, 1988·Nature·D L VauxJ M Adams
May 1, 1988·The Journal of Endocrinology·C P RoddaT J Martin
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A F StewartA E Broadus
Oct 1, 1983·The Journal of Clinical Investigation·S B RodanG A Rodan
Oct 30, 1980·Nature·C Nüsslein-Volhard, E Wieschaus
Aug 1, 1995·Molecular and Cellular Biology·J E HendersonA C Karaplis
Apr 7, 1995·Science·E SchipaniH Jüppner
Jun 30, 1995·The Journal of Biological Chemistry·T B UsdinT I Bonner
Sep 1, 1994·The Journal of Cell Biology·N AmizukaA C Karaplis
Jan 1, 1994·Endocrinology·K LeeG V Segre
Feb 1, 1994·Genes & Development·A C KaraplisR C Mulligan
May 1, 1993·Bone·K LeeG V Segre
Sep 1, 1995·Calcified Tissue International·T TsukazakiS Yamashita
Apr 10, 1996·Developmental Biology·N AmizukaD Goltzman
Aug 2, 1996·Science·A VortkampC J Tabin
Aug 2, 1996·Science·B LanskeH M Kronenberg
Jan 13, 1997·The Journal of Cell Biology·M AmlingR Baron
Feb 14, 1998·Archives of Oral Biology·K YamazakiT Kuroda
Citations
Apr 19, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Erik Kern HarringtonKathy K H Svoboda
Oct 20, 2000·Clinical Orthopaedics and Related Research·R S GoomerD Amiel
Mar 3, 2011·Neurosurgical Focus·Lana D ChristianoIra M Goldstein
May 8, 2019·International Journal of Environmental Research and Public Health·Benjamin Ka Seng ThongKok-Yong Chin
Oct 30, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Erik Kern HarringtonKathy K H Svoboda