Parathyroid hormone(1-34) exhibits more comprehensive effects than celecoxib in cartilage metabolism and maintaining subchondral bone micro-architecture in meniscectomized guinea pigs

Osteoarthritis and Cartilage
M-W DaiLiu Zhang

Abstract

To evaluate the effects of PTH(1-34) on cartilage, subchondral bone mass and structure in medial meniscectomized guinea pigs and compare them to those of celecoxib (CLX). Forty-eight 3-month-old male Hartley albino guinea pigs received either sham or medial meniscectomy (MNX) operations. One week after the procedure, meniscectomized animals began 12 weeks of treatment by oral administration of CLX (20 mg/kg, daily), subcutaneous injection of PTH (1-34) (24 μg/kg, 5 days/week), or normal saline for MNX group. All animals were euthanized 12 weeks later, cartilage degeneration and subchondral bone micro-architecture was analyzed. OARSI scores indicated cartilage degeneration was partially inhibited by either CLX or PTH(1-34). Cartilage was significantly thicker in PTH(1-34)-treated animals than in CLX-treated animals. Both CLX and PTH(1-34) treatment were associated with lower ADAMTS-4 and periostin expression than MNX. MMP-13 expression in PTH(1-34) group was significantly lower than that in CLX group. However, AGG expression and the ratio of Col-II/MMP-13 expression in PTH(1-34) group were significantly higher than in the CLX group. Micro-CT analysis showed BMD, BV/TV, and Tb.Th levels to be significantly lower in the MNX group ...Continue Reading

References

Apr 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K J IbbotsonR W Boyce
Sep 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C C Liu, D N Kalu
Aug 7, 1999·The Journal of Biological Chemistry·A K HarveyS Chandrasekhar
Oct 12, 2001·Trends in Endocrinology and Metabolism : TEM·E K BarbehennS M Wolfe
Oct 18, 2001·Current Opinion in Rheumatology·W B van den Berg
Apr 11, 2002·Cell Research·Chris KianiBurton B Yang
Aug 8, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sanjeev KakarGeorge L Barnes
Dec 4, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Erik Kern HarringtonKathy K H Svoboda
Dec 15, 2010·International Journal of Molecular Sciences·Dinghua JiangHuilin Yang
Sep 23, 2011·Science Translational Medicine·Erik R SampsonMichael J Zuscik
Jun 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yunsheng OuXiaoji Luo
Jun 6, 2013·Biomechanics and Modeling in Mechanobiology·Corinne R HenakJeffrey A Weiss
Oct 23, 2013·Cellular and Molecular Life Sciences : CMLS·Simon J ConwayAkira Kudo
Mar 26, 2014·Osteoarthritis and Cartilage·P OrthH Madry
May 13, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Allan Yi LiuGaoliang Ouyang
Nov 11, 2014·Journal of Proteome Research·Lucía LouridoCristina Ruiz-Romero
Apr 18, 2015·Joint, Bone, Spine : Revue Du Rhumatisme·Sittisak HonsawekNapaphat Jirathanathornnukul
Jul 7, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hannah M PaulyTammy L Haut Donahue

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Citations

Dec 19, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yugo MoritaShuichi Matsuda
Feb 12, 2017·BMC Musculoskeletal Disorders·Jian-Guo ChuLiu Zhang
Sep 26, 2020·International Journal of Molecular Sciences·Ufuk Tan TimurPieter J Emans
Jan 22, 2021·Nature Communications·Natalie C ButterfieldJ H Duncan Bassett

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