Parathyroid reoperation with use of technetium 99m sestamibi radiolocalization and an intraoperative gamma counter.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
S Feng, F D Moore

Abstract

To describe a new intraoperative technique for localization of abnormal parathyroid tissue. We report a case and discuss the difficulties encountered in reexploration of the neck area. Parathyroid reoperation remains a formidable challenge to even the most experienced endocrine surgeon. Despite the advances in radiographic imaging and localization techniques, accurate intraoperative identification of abnormal parathyroid tissue in a scarred field with obliterated anatomic planes is frequently tedious and occasionally unsuccessful. In a 48-year-old woman with hyperparathyroidism, extensive exploration of the area identified (on the basis of preoperative magnetic resonance imaging and technetium 99m sestamibi scans) as suspicious for the presence of abnormal parathyroid tissue revealed only an aberrant vein. With use of a handheld gamma counter to provide intraoperative guidance during parathyroid reexploration after preoperative intravenous injection of technetium 99m sestamibi, quick identification of a small, intrathyroidal, fifth gland adenoma responsible for persistent primary hyperparathyroidism was facilitated. Because of suboptimal precision and specificity, current preoperative localization studies can occasionally provi...Continue Reading

References

Dec 1, 1992·American Journal of Surgery·C E Silver, F J Velez
Oct 1, 1991·American Journal of Surgery·G L IrvinD L Prudhomme
Sep 18, 1971·British Medical Journal·N E Dudley
Jun 1, 1982·American Journal of Surgery·M H Wheeler, J S Wade
Aug 1, 1981·Annals of Surgery·W C McGarity, A L Goldman
Mar 1, 1993·American Journal of Surgery·A F DeromF E Derom
Aug 1, 1994·Archives of Surgery·J M RodriquezO H Clark

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Citations

Jan 31, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Francis D Moore
Sep 24, 1999·Annals of Surgery·F D MooreM Tanasijevic

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