Parathyroid scintigraphy findings in chronic kidney disease patients with recurrent hyperparathyroidism.

European Journal of Nuclear Medicine and Molecular Imaging
E HindiéPablo Ureña-Torres

Abstract

Parathyroidectomy (PTX), either subtotal or total with forearm autografting, is a well-established treatment for refractory renal hyperparathyroidism (RHPT). However, 20-30% of patients develop persistent or recurrent disease. Obtaining accurate localization before reoperation is difficult. The study group comprised 21 consecutive adult patients (18 undergoing haemodialysis and 3 with a renal graft) imaged using (99m)Tc-sestamibi/(123)I subtraction scintigraphy. Of the 21 patients, 12 had undergone one previous PTX and the other 9 between two and four parathyroid operations. All patients had symptoms and signs of severe RHPT. The mean serum PTH level was 1,142 pg/ml. (99m)Tc-Sestamibi and (123)I images were recorded simultaneously. Imaging views comprised a planar view of the neck and mediastinum, followed by a magnified pinhole view over the thyroid bed area. If parathyroid ectopy was detected, SPECT or SPECT-CT was performed. The forearm was imaged in case of autograft. Parathyroid scintigraphy was negative in one patient and positive in the other 20 (sensitivity 95.2%). One patient had uptake corresponding to two unresected parathyroid glands. Recurrence at the site of the partially resected gland or autograft was seen in 11...Continue Reading

References

Jan 1, 1991·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M KesslerP Mathieu
Jul 1, 1991·World Journal of Surgery·D CasanovaC Dubost
Aug 1, 1989·Archives of Surgery·K E Levin, O H Clark
Mar 1, 1988·Annals of Surgery·M Rothmund, P K Wagner
May 1, 1995·The Journal of Clinical Investigation·A ArnoldT B Drüeke
Oct 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C Stehman-BreenD Sherrard
May 18, 2000·The New England Journal of Medicine·W G GoodmanI B Salusky
May 10, 2001·World Journal of Surgery·T M PawlikN Thompson
Sep 20, 2001·Journal of the American Society of Nephrology : JASN·Santhi K GaneshFriedrich K Port
Feb 19, 2002·Journal of the American College of Cardiology·Paolo RaggiGlenn M Chertow
May 20, 2003·Kidney International. Supplement·Rosa JofréRafael Pérez García
May 20, 2003·Kidney International. Supplement·Maria Paz MarcoElvira Fernández
Apr 9, 2004·The New England Journal of Medicine·Geoffrey A BlockWilliam G Goodman
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Geoffrey A BlockGlenn M Chertow
Aug 28, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tetsuhiko SatoMasafumi Fukagawa
Oct 22, 2004·Kidney International·Bryan KestenbaumCatherine Stehman-Breen
Nov 26, 2004·Journal of the American Society of Nephrology : JASN·Robert N FoleyAllan J Collins
May 27, 2005·Journal of the American Society of Nephrology : JASN·Orlando GutierrezMyles Wolf
Sep 1, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anthony J BleyerJ Jeffrey Carr
Jan 26, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Domenico RubelloMilton D Gross
Mar 29, 2006·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Pablo Ureña TorresGérard Friedlander
Jan 16, 2007·World Journal of Surgery·Susumu MatsuokaToyonori Tsuzuki
Mar 14, 2007·World Journal of Surgery·Susumu MatsuokaHiroshi Takami
Jul 20, 2007·Journal of the American Society of Nephrology : JASN·Kyle D RudserBryan Kestenbaum

❮ Previous
Next ❯

Citations

Apr 22, 2014·International Journal of Endocrinology and Metabolism·William Robert FoleyTom Gorey
Oct 24, 2014·AJR. American Journal of Roentgenology·David Taïeb, Elif Hindié
Jan 10, 2012·Metabolism: Clinical and Experimental·Mirella P HageGhada El-Hajj Fuleihan
Feb 8, 2011·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Érica Dorigatti de ÁvilaMário Francisco Real Gabrielli
Oct 19, 2016·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Thomas Hanna, Jacob A Akoh
Jul 1, 2014·Endocrine Reviews·Ka Kit WongMilton D Gross
Feb 3, 2015·Nuclear Medicine Communications·Ka Kit WongBen A Dwamena
Apr 13, 2019·Clinical Kidney Journal·Pablo A Ureña-TorresUNKNOWN ERA-EDTA CKD-MBD Working Group
Apr 28, 2021·Pediatric Radiology·Hedieh KhalatbariMarguerite T Parisi
Apr 11, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Elif HindiéDavid Taïeb

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.