Parathyroidectomy and survival among Japanese hemodialysis patients with secondary hyperparathyroidism

Kidney International
Hirotaka KomabaMasafumi Fukagawa

Abstract

Parathyroidectomy (PTx) drastically improves biochemical parameters and clinical symptoms related to severe secondary hyperparathyroidism (SHPT) but the effect of PTx on survival has not been adequately investigated. Here we analyzed data on 114,064 maintenance hemodialysis patients from a nationwide registry of the Japanese Society for Dialysis Therapy to evaluate the associations of severity of SHPT and history of PTx with 1-year all-cause and cardiovascular mortality. We then compared the mortality rate between 4428 patients who had undergone PTx and 4428 propensity score-matched patients who had not despite severe SHPT. During a 1-year follow-up, 7926 patients of the entire study population died, of whom 3607 died from cardiovascular disease. Among patients without a history of PTx, severe SHPT was associated with an increased risk for all-cause and cardiovascular mortality. However, such an increased risk of mortality was not observed among patients with a history of PTx. In the propensity score-matched analysis, patients who had undergone PTx had a 34% and 41% lower risk for all-cause and cardiovascular mortality, respectively, compared to the matched controls. The survival benefit associated with PTx was robust in severa...Continue Reading

References

Apr 1, 1996·The Journal of Clinical Endocrinology and Metabolism·O KiforE M Brown
Feb 19, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S StrackeF Keller
Jan 7, 2000·Journal of the American College of Surgeons·F F ChouS M Sheen-Chen
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Y TominagaH Takagi
Feb 27, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Michitaka NagashimaKazuo Haze
Jun 24, 2004·Journal of the American Society of Nephrology : JASN·Gérard M LondonMarie-Christine de Vernejoul
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Geoffrey A BlockGlenn M Chertow
Aug 28, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tetsuhiko SatoMasafumi Fukagawa
Oct 22, 2004·Kidney International·Bryan KestenbaumCatherine Stehman-Breen
Sep 1, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anthony J BleyerJ Jeffrey Carr
Dec 28, 2006·American Journal of Physiology. Renal Physiology·Gloria RashidSydney Benchetrit
Jul 20, 2007·Journal of the American Society of Nephrology : JASN·Kyle D RudserBryan Kestenbaum
Nov 6, 2007·Surgery·Valeria Costa-HongJose Jayme G De Lima
Jun 3, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Francesca TentoriFriedrich K Port
Jan 15, 2009·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·UNKNOWN Guideline Working Group, Japanese Society for Dialysis Therapy
Oct 16, 2010·Journal of the American Society of Nephrology : JASN·Takayuki HamanoYoshitaka Isaka
Oct 12, 2011·The Journal of Clinical Investigation·Christian FaulMyles Wolf
Nov 6, 2012·The New England Journal of Medicine·UNKNOWN EVOLVE Trial InvestigatorsPatrick S Parfrey
Apr 5, 2013·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Masatomo TaniguchiUNKNOWN Committee of Renal Data Registry of the Japanese Society for Dialysis Therapy
May 7, 2013·BMC Nephrology·Jean-Philippe LafranceJacques Le Lorier
May 11, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Jing ZhangNingning Wang
Jan 31, 2014·The Journal of Clinical Endocrinology and Metabolism·Hiroo TakahashiMasafumi Fukagawa

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Citations

Aug 1, 2015·Kidney International·Julia J Scialla, Myles Wolf
Sep 1, 2015·Kidney International·Hirotaka KomabaMasafumi Fukagawa
Sep 1, 2015·Kidney International·Rosilene M EliasRosa M A Moyses
Sep 18, 2015·International Urology and Nephrology·Diana MoldovanMirela Gherman-Căprioară
Aug 13, 2015·Seminars in Dialysis·Hirotaka Komaba, Masafumi Fukagawa
Sep 17, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kerstin M IvarssonMartin Almquist
Aug 16, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Piergiorgio Messa
Feb 26, 2016·Wiener medizinische Wochenschrift·Emanuel Zitt, Karl Lhotta
Jun 9, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Sun Moon KimGlenn M Chertow
Jun 11, 2016·Kidney International·Hirotaka Komaba, Masafumi Fukagawa
Dec 10, 2015·Journal of the American Society of Nephrology : JASN·Josep M CruzadoJosep M Grinyó
Jan 17, 2016·Journal of the American Society of Nephrology : JASN·Masafumi Fukagawa, Tilman B Drüeke
Oct 21, 2016·Clinical and Experimental Nephrology·Takayo MiyakogawaMasafumi Fukagawa
Nov 4, 2016·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·D SylvesterJ England
Dec 17, 2016·Revista do Colégio Brasileiro de Cirurgiões·Fabio Luiz DE Menezes MontenegroRosa Maria Affonso Moyses
Apr 5, 2017·Current Opinion in Nephrology and Hypertension·Hirotaka KomabaMasafumi Fukagawa
Jul 6, 2017·Seminars in Dialysis·Amr El-HusseiniB Peter Sawaya
Jul 26, 2017·Scandinavian Journal of Clinical and Laboratory Investigation·Lijie MaZhongxin Li
Feb 1, 2017·Scientific Reports·Yoshitsugu ObiUNKNOWN Committee of Renal Data Registry of the Japanese Society for Dialysis Therapy
Nov 10, 2018·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Masahide MizobuchiFumihiko Koiwa
Feb 28, 2019·Drugs·Rowena Delos SantosThin Thin Maw
May 13, 2018·BMC Nephrology·Andreea Corina SofronieGiorgina Barbara Piccoli
Jan 20, 2016·Current Opinion in Nephrology and Hypertension·Andrew L Lundquist, Sagar U Nigwekar
Oct 7, 2017·Current Opinion in Nephrology and Hypertension·Keith E Eidman, James B Wetmore
Jan 4, 2017·Clinical and Experimental Nephrology·Hirotaka KomabaMasafumi Fukagawa
May 22, 2018·International Journal of Endocrinology·Kenichi AkiyamaKazuhiro Shiizaki
Jun 20, 2020·Expert Review of Endocrinology & Metabolism·Naoto HamanoMasafumi Fukagawa
Dec 13, 2016·Clinical and Experimental Nephrology·Takayuki HamanoYoshitaka Isaka

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