PMID: 3769400Nov 1, 1986Paper

Parathyroidectomy, cardiovascular reactivity and calcium distribution in aorta and heart of spontaneously hypertensive rats

Clinical Science
R SchleifferA Gairard

Abstract

In order to elucidate the mechanisms by which parathyroidectomy (PTX), performed in young spontaneously hypertensive rats (SHR), delays the development and attenuates the level of hypertension, we studied, in vivo, cardiovascular reactivity (CVR, blood pressure response to bolus noradrenaline administration), aortic calcium distribution and cardiac calcium content in SHR with or without parathyroid glands. PTX was performed in 6-week-old animals and experiments were done in pretreated anaesthetized animals 2 and 22 weeks after surgery. A significantly decreased CVR was observed 22 weeks after PTX in SHR-PTX as compared with controls. These data are not specific for hypertensive animals since similar data are also obtained on normotensive Wistar rats treated in an identical fashion. In addition, after PTX in SHR and Wistar rats myocardial (auricle and ventricle) calcium content was more rapidly reduced (after 2 weeks) than aortic membrane-bound and cellular calcium fractions. The present studies established that PTX decreased CVR and alters calcium content and distribution in the cardiovascular systems of rats from hypertensive and normotensive strains. Furthermore, the results confirm a requirement for the parathyroid glands in...Continue Reading

Citations

Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·A WiecekJ F Mann
Dec 14, 1987·The American Journal of Cardiology·M Martínez-MaldonadoL D Dworkin
Jun 1, 1992·International Journal of Cardiology·R Schleiffer
Nov 1, 1988·The American Journal of Medicine·S G RostandR G Fraser
Mar 1, 1991·Clinical and Experimental Pharmacology & Physiology·R SchleifferA Gairard
Jan 1, 1988·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·F Yang, P A Nickerson
Oct 3, 1999·Physiological Reviews·J Zicha, J Kunes

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