Parathyroidectomy followed by kidney transplantation can improve bone mineral density in patients with secondary hyperparathyroidism

Transplantation
Fong-Fu ChouChien-Te Lee

Abstract

We studied bone mineral density (BMD) after total parathyroidectomy plus autotransplantation (TPTD plus AT) followed by kidney transplantation in patients with symptomatic secondary hyperparathyroidism. We recruited 43 patients who were operated on with TPTD plus AT for this study. Group A (n=36) patients continued hemodialysis regularly thereafter; Group B (n=7) patients were followed by cadaveric kidney transplantation. In group A, serum calcium, phosphorus, alkaline phosphatase (Alk-ptase) and intact parathyroid hormone (iPTH) levels were measured at baseline, 1 week, and in the late follow-up period. In group B, serum calcium, phosphorus, Alk-ptase and iPTH levels were measured at baseline, 1 week after parathyroidectomy, and in the late follow-up period after kidney transplantation. The BMD of lumbar spine, femur, ulna and radius was measured with dual x-ray absorptiometry at baseline, and again at 1 year in group A and at 1 year after kidney transplantation in group B. At 1 week after TPTD plus AT, calcium, phosphorus, and iPTH levels decreased significantly but Alk-ptase did not. In the late follow up period calcium, phosphorus, Alk-ptase and iPTH levels decreased significantly compared with those at baseline. In group A...Continue Reading

References

Aug 22, 1991·The New England Journal of Medicine·B A JulianL D Quarles
Aug 23, 1973·The New England Journal of Medicine·D S DavidL M Sherwood
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·H Klinkmann, J Vienken
Jun 1, 1995·The Surgical Clinics of North America·K S Packman, M J Demeure
Jan 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F F HorberP Jaeger
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J V TorregrosaM J Martinez de Osaba
Jul 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·V PichetteD Ouimet
May 22, 1998·Transplantation Proceedings·I IşiklarE A Niron
Jun 24, 1998·Annals of Surgery·J D KerbyA G Diethelm
Jan 7, 2000·Journal of the American College of Surgeons·F F ChouS M Sheen-Chen
Aug 15, 2002·Transplantation·Eileen A O'ShaughnessyBertram L Kasiske
Sep 28, 2002·Transplantation·Stéphanie DurieuxCorinne Isnard Bagnis
Oct 20, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sandro MazzaferroFrancesco Pugliese
Nov 14, 2006·Transplantation Proceedings·R GallegoL Palop
May 26, 2007·Transplantation Proceedings·N BayatP K Elizeii
Jul 31, 2007·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Yoshihiro TominagaUNKNOWN Kazuharu Uchida (Yagoto PTx Forum)
Aug 30, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K BorchhardtM Haas

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Citations

Sep 18, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·UNKNOWN European Renal Best Practice Transplantation Guideline Development Group
Feb 26, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Betti SchaeferClaus Peter Schmitt
Nov 8, 2015·World Journal of Surgery·Takayuki YamamotoYoshihiko Watarai
May 19, 2017·The British Journal of Surgery·R R DulferT M van Ginhoven
Oct 28, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

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