Paratracheal lymph node dissection in cancer of the larynx, hypopharynx, and cervical esophagus: the need for guidelines

Head & Neck
Remco de BreeAlfio Ferlito

Abstract

In laryngeal, hypopharyngeal, and cervical esophageal carcinomas, the paratracheal lymph nodes (PTLN) may be at risk for lymph node metastasis. The presence of PTLN metastasis is an important prognostic factor for the development of mediastinal and distant metastases, stomal recurrence, and disease-free and overall survival. Studies on PTLN metastasis are scarce. In most studies, PTLN dissection has not been routinely performed, and selection criteria for PTLN dissection are usually not well defined. Therefore, in most reported studies, selection bias is present and results are difficult to compare. The reported prevalence of PTLN metastases varies according to the site and stage of the primary tumor: subglottic cancer, transglottic cancer, and glottic cancer with subglottic extension have a higher risk of PTLN metastases. Diagnostic imaging is not sufficiently reliable to detect occult PTLN metastases and avoid unnecessary PTLN dissections. PTLN dissection is associated with limited morbidity, but damage to major vessels may occur, and because of exposure of these vessels PTLN may increase the morbidity of fistulae that can occur after total laryngectomy. The dissection may produce hypocalcemia, if performed bilaterally. Never...Continue Reading

References

Feb 1, 1991·Clinical Otolaryngology and Allied Sciences·T J RockleyA P Reid
Jan 1, 1993·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·R S WeberH Goepfert
Jan 1, 1996·Head & Neck·X LeónL de Andrés
Sep 17, 2002·British Journal of Cancer·J A WernerTh Behr
May 15, 2004·Clinical Otolaryngology and Allied Sciences·Z Petrovic, V Djordjevic
Jul 9, 2004·American Journal of Otolaryngology·João Gonçalves Filho, Luiz Paulo Kowalski
May 4, 2005·The Laryngoscope·Robin E PlaatC René Leemans
Oct 26, 2005·The Annals of Thoracic Surgery·Shiro NagataniMasayuki Imamura
Dec 20, 2005·American Journal of Otolaryngology·Jimmy Garas, W Fred McGuirt
Jul 11, 2006·European Journal of Radiology·Redina LjumanovicJonas A Castelijns
Mar 17, 2007·Acta Oto-laryngologica·Benjamin LallemantJean-Gabriel Lallemant
Jul 26, 2008·Otolaryngologia polska. The Polish otolaryngology·Aleksandra Kruk-ZagajewskaJacek Banaszewski
Mar 24, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Sandro J StoeckliGary L Ross
Nov 17, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Annalisa M Lo GalboC René Leemans
Jul 24, 2010·Head & Neck·Jesus E MedinaJochen A Werner

❮ Previous
Next ❯

Citations

Feb 4, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·G RizzottoG Succo
Dec 30, 2014·Radiation Oncology·Anna MerlottiUNKNOWN Italian Association of Radiation Oncology
Sep 18, 2012·Otolaryngologic Clinics of North America·Dana M Hartl
Jul 9, 2013·The Laryngoscope·Eun-Jae ChungYoung-Soo Rho
Oct 22, 2014·Acta Oto-laryngologica·Ersoy DoganAhmet Omer Ikiz
Apr 30, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Hae Sang ParkYoung Soo Rho
Jan 10, 2012·Oral Oncology·Thomas T A PetersRemco de Bree
Dec 15, 2017·Journal of Cancer Research and Therapeutics·Zhi-Yi WangHong-Liang Zheng
Aug 3, 2017·The Annals of Otology, Rhinology, and Laryngology·Jinyu MeiYehai Liu
Mar 7, 2019·Japanese Journal of Clinical Oncology·Nayuta TsushimaMasakazu Ikeda
Mar 19, 2011·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·L van der PuttenC R Leemans
Dec 21, 2019·Indian Journal of Surgical Oncology·Smriti PandaSuman Bhasker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.