Paraurethral striated muscular structures and pelvic floor muscles contribute to resting urethral closure pressure in rats.

International Urogynecology Journal
Hung-Yen ChinHann-Chorng Kuo

Abstract

We investigated physiological functions of the extraordinary muscular structure in the paraurethral area with pelvic floor muscle and the impact of these muscular structures on the resting maximal urethral closure pressure (MUCP) in rats. Sixteen female Wister rats were divided into four groups: Groups I and II rats received 5 and 2.5 IU botulinum toxin A (BoNT-A), respectively, injected into the bilateral paraurethral striated muscles. Group III rats received 2.5 IU BoNT-A injected into the bilateral pelvic floor muscles, and group IV rats received 2.5 IU BoNT-A injected into the unilateral pelvic floor muscles. Measurements of MUCP were made at different time points after BoNT-A injection. All groups showed a rapid reduction in average MUCP by 70-80 % after BoNT-A injection, regardless of injection site or side. Paraurethral striated muscular structures and the pelvic floor muscles possess the function of maintaining resting MUCP in rats.

References

Sep 25, 2003·American Journal of Physiology. Renal Physiology·Ron J JankowskiDavid A Vorp
Apr 10, 2007·Annals of the New York Academy of Sciences·James A Ashton-Miller, John O L DeLancey
Apr 22, 2008·The Journal of Urology·John O L DeLanceyJames A Ashton-Miller
May 16, 2009·Current Opinion in Urology·Gordon Hosker
May 21, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karl B Thor, William C de Groat
May 22, 2010·International Urogynecology Journal·Hung-Yen ChinHsiu-Ping Yang

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Citations

Mar 13, 2017·International Urogynecology Journal·Amanda M StewartMarianna Alperin

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