Paravertebral block can attenuate cytokine response when it replaces general anesthesia for cancer breast surgeries

Saudi Journal of Anaesthesia
Sherif S Sultan

Abstract

Cytokine release is a well-known response to surgery especially when it is linked to cancer. Paravertebral block (PVB) is the suitable regional anesthesia for breast surgery. We tested the effect of replacing general anesthesia (GA) with PVB on cytokine response during and after surgeries for cancer breast. Controlled randomized study. Forty cancer breast patients were divided in two groups; Group I received PVB and Group II received GA during performance of unilateral breast surgery without axillary clearance. Plasma concentrations of interleukin (IL)-6, IL-10, IL-12 and interferon-γ (IFN-γ) were measured and IL-10/IFN-γ were estimated in the following points; before starting PVB in Group I or induction of GA in Group II (Sample A), before skin incision (Sample B), at the end of procedure before shifting out of operating room (Sample C), 4-h post-operatively (Sample D) and 24-h post-operatively (Sample E). unpaired Student t-test. IL-6 increased progressively in both groups with statistically significant lower levels in samples C and D in Group I. IL-10 levels showed progressive increasing in both groups without differences between groups. IL-12 showed progressive decrease in both groups with statistically significant higher l...Continue Reading

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Citations

Aug 4, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Claudia ClaroniEster Forastiere
Jul 3, 2015·Physiological Reviews·O FriedrichL Larsson
Feb 26, 2021·The Cochrane Database of Systematic Reviews·Anjolie ChhabraMani Kalaivani

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Methods Mentioned

BETA
sedation
enzyme
linked immunosorbent assays
enzyme-linked immunosorbent assays

Software Mentioned

SPSS

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