Paraxis is a basic helix-loop-helix protein that positively regulates transcription through binding to specific E-box elements.

The Journal of Biological Chemistry
Jeanne Wilson-RawlsA Rawls

Abstract

Members of the Twist subfamily of basic helix-loop-helix transcription factors are important for the specification of mesodermal derivatives during vertebrate embryogenesis. This subfamily includes both transcriptional activators such as scleraxis, Hand2, and Dermo-1 and repressors such as Twist and Hand1. Paraxis is a member of this subfamily, and it has been shown to regulate morphogenetic events during somitogenesis, including the transition of cells from mesenchyme to epithelium and maintaining anterior/posterior polarity. Mice deficient in paraxis exhibit a caudal truncation of the axial skeleton and fusion of the vertebrae. Considering the developmental importance of paraxis, it is important for future studies to understand the molecular basis of its activity. Here we demonstrate that paraxis can function as a transcriptional activator when it forms a heterodimer with E12. Paraxis is able to bind to a set of E-boxes that overlaps with the closely related scleraxis. Paraxis expression precedes that of scleraxis in the region of the somite fated to form the axial skeleton and tendons and is able to direct transcription from an E-box found in the scleraxis promoter. Further, in the absence of paraxis, Pax-1 is no longer expr...Continue Reading

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Citations

Jun 16, 2009·Histochemistry and Cell Biology·Venugopal Rao MittapalliMartin Scaal
Aug 28, 2012·The Journal of Biological Chemistry·Douglas M AndersonAlan Rawls
Jun 26, 2007·Cells, Tissues, Organs·Christine L ChafferElizabeth D Williams
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Sep 17, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Megan RowtonAlan Rawls
May 27, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Romel Sebastián Sánchez, Sara Serafina Sánchez
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