Parent-Reported Symptoms of Sleep-Disordered Breathing Are Associated With Increased Behavioral Problems at 2 Years of Age: The Canadian Healthy Infant Longitudinal Development Birth Cohort Study

Sleep
Sukhpreet K TamanaPiush J Mandhane

Abstract

To examine the association between the age of onset and duration of parent-reported symptoms of sleep-disordered breathing (SDB) and behavioral problems at age 2. Parent-reported SDB symptoms were assessed quarterly between 3 months and 2 years among 583 Canadian Healthy Infant Longitudinal Development Edmonton-site participants. Parent-reported SDB symptoms were clustered into phenotypes using group-based trajectory analysis based on age of onset and duration of symptoms. Home-based polysomnography (PSG) was completed at 1 year. The Child Behavior Checklist preschool-version (Mean T-score 50, standard deviation 10 points) assessed total, externalizing (attention), and internalizing (anxiety, depression) behaviors at 2 years. Four phenotypes were identified: no SDB (64.7%), early-onset SDB (15.7%, peak symptoms at 9 months), late-onset (14.2%, peak symptoms at 18 months), and persistent SDB symptoms (5.3%, peak symptoms from 3 through 24 months). Persistent SDB (9.5 points, 95% CI 1.7, 17.2; p = .02) predicted the greatest magnitude of effect of total behavior problems, compared with children without SDB. Children with early-onset SDB (3.5 points, 95% CI 1.6, 5.4; p ≤ .001) and late-onset SDB (6.1 points 95% CI 4.0, 8.3; p ≤ .0...Continue Reading

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Citations

May 17, 2019·Behavioral Sleep Medicine·Reut GruberJose Arturo Santisteban
Jun 15, 2019·Pediatric Pulmonology·Courtney M Quinlan, Ignacio E Tapia
Nov 22, 2020·Journal of Neurodevelopmental Disorders·Caroline Greiner de MagalhãesCarolyn B Mervis
Sep 9, 2020·American Journal of Respiratory and Critical Care Medicine·Charmaine van EedenPiushkumar J Mandhane
Aug 10, 2021·Journal of Clinical and Translational Science·Leslie C ThompsonMatthew W Gillman

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