Parental age effects on neonatal white matter development.

NeuroImage. Clinical
Oliver Gale-GrantDafnis Batalle

Abstract

Advanced paternal age is associated with poor offspring developmental outcome. Though an increase in paternal age-related germline mutations may affect offspring white matter development, outcome differences could also be due to psychosocial factors. Here we investigate possible cerebral changes prior to strong environmental influences using brain MRI in a cohort of healthy term-born neonates. We used structural and diffusion MRI images acquired soon after birth from a cohort (n = 275) of healthy term-born neonates. Images were analysed using a customised tract based spatial statistics (TBSS) processing pipeline. Neurodevelopmental assessment using the Bayley-III scales was offered to all participants at age 18 months. For statistical analysis neonates were compared in two groups, representing the upper quartile (paternal age ≥38 years) and lower three quartiles. The same method was used to assess associations with maternal age. In infants with older fathers (≥38 years), fractional anisotropy, a marker of white matter organisation, was significantly reduced in three early maturing anatomical locations (the corticospinal tract, the corpus callosum, and the optic radiation). Fractional anisotropy in these locations correlated pos...Continue Reading

Citations

Feb 4, 2021·Human Reproduction·R John Aitken, Hassan W Bakos
Jul 30, 2021·Frontiers in Neuroscience·Anni CopelandJetro J Tuulari

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Methods Mentioned

BETA
sedation
dissect

Software Mentioned

GraphPad Prism
TK
FSL TBSS
FSL
DTI
TBSS
STATA

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