Parental effect of DNA (Cytosine-5) methyltransferase 1 on grandparental-origin-dependent transmission ratio distortion in mouse crosses and human families.

Genetics
Lanjian YangAnna K Naumova

Abstract

Transmission ratio distortion (TRD) is a deviation from the expected Mendelian 1:1 ratio of alleles transmitted from parents to offspring and may arise by different mechanisms. Earlier we described a grandparental-origin-dependent sex-of-offspring-specific TRD of maternal chromosome 12 alleles closely linked to an imprinted region and hypothesized that it resulted from imprint resetting errors in the maternal germline. Here, we report that the genotype of the parents for loss-of-function mutations in the Dnmt1 gene influences the transmission of grandparental chromosome 12 alleles. More specifically, maternal Dnmt1 mutations restore Mendelian transmission ratios of chromosome 12 alleles. Transmission of maternal alleles depends upon the presence of the Dnmt1 mutation in the mother rather than upon the Dnmt1 genotype of the offspring. Paternal transmission mirrors the maternal one: live-born offspring of wild-type fathers display 1:1 transmission ratios, whereas offspring of heterozygous Dnmt1 mutant fathers tend to inherit grandpaternal alleles. Analysis of allelic transmission in the homologous region of human chromosome 14q32 detected preferential transmission of alleles from the paternal grandfather to grandsons. Thus, paren...Continue Reading

References

Sep 15, 1994·American Journal of Medical Genetics·S NankoH Kazamatsuri
Jul 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J M TraslerF Ghibu
Sep 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·F Pardo-Manuel de VillenaC Sapienza
Aug 27, 1998·American Journal of Human Genetics·K W BromanJ L Weber
Oct 23, 1998·Journal of Medical Genetics·P GeorgiadesA C Ferguson-Smith
Oct 30, 1998·Biochemical and Biophysical Research Communications·J S Tash, G E Bracho
Aug 4, 1999·Nature Genetics·I A EavesJ A Todd
Dec 3, 1999·American Journal of Medical Genetics·A D Paterson, A Petronis
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·P GeorgiadesA C Ferguson-Smith
Jul 11, 2001·Genome Génome / Conseil National De Recherches Canada·A K NaumovaK Morgan
Jan 5, 2002·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Sylvie CroteauAnna K Naumova
Feb 15, 2002·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Y ZhengP A Martin-DeLeon
Feb 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Vardhman K RakyanEmma Whitelaw
Oct 29, 2003·Journal of Andrology·Tamara L J KellyJacquetta M Trasler
Nov 18, 2003·Annual Review of Genetics·Mary F Lyon
Dec 19, 2003·American Journal of Human Genetics·Sebastian ZöllnerJonathan K Pritchard
Sep 16, 2004·American Journal of Medical Genetics. Part a·David A StevensonNicola Longo
Jan 7, 2005·The Journal of Biological Chemistry·Yeoung-Gyu KoKunio Shiota
Apr 30, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Sylvie CroteauAnna K Naumova
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Jan 5, 2006·European Journal of Human Genetics : EJHG·Nicola L DeanAsangla Ao
May 26, 2006·Nature·Minoo RassoulzadeganFrançois Cuzin
Oct 4, 2006·BMC Genetics·Ekaterina Y SteshinaJennifer V Schmidt
Dec 29, 2006·The New England Journal of Medicine·Medea ImbodenPascale Guicheney

❮ Previous
Next ❯

Citations

Jun 26, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Aabida SaferaliAnna K Naumova
Dec 18, 2012·Human Genetics·Lam Opal HuangClaire Infante-Rivard
Sep 13, 2012·Genome Génome / Conseil National De Recherches Canada·Aabida SaferaliAnna K Naumova
Sep 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Delphine CarougeJoseph H Nadeau

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.