PMID: 12787908Jun 6, 2003Paper

Parental exposure to low-dose X-rays in Drosophila melanogaster induces early emergence in offspring, which can be modulated by transplantation of polar cytoplasm

Mutation Research
Tomoko KanaoNorimasa Nohara

Abstract

In recent years there has been growing concern over the biological effects of low-dose X-rays, but few studies have addressed this issue. Our laboratory had observed flies (Drosophila melanogaster) irradiated with low-dose X-rays tend to emerge earlier than normal flies. This observation led us to quantitatively examine the effects of low-dose X-irradiation on development in the fly. Following exposure of prepupal (day 5) flies to 0.5 Gy X-rays, the time to emergence was slightly shorter than in the sham controls. This tendency was increased when the X-ray exposure came during the pupal stage (day 7). In these flies, the time to eclosion decreased significantly, by an average of 30 h sooner than sham controls. A further experiment examined whether such radiation effects could be observed in the unexposed F1 generation of exposed individuals. Greater radiation effects on early F1 emergence were seen when the time between exposure and mating was 3 days, indicating an effect on early spermatid development. Early F1 emergence was also observed after exposure of female flies to X-rays during late previtellogeny. Furthermore, rapid emergence could be induced in the F1 embryos of unexposed parents by transferring the polar cytoplasm (...Continue Reading

References

Jan 1, 1996·Annual Review of Cell and Developmental Biology·A Williamson, R Lehmann
May 13, 1998·Developmental Biology·T T SuP H O'Farrell
Oct 5, 2002·Journal of Environmental Radioactivity·Tomoko KanaoTakeshi Yamada
Oct 15, 1941·Proceedings of the National Academy of Sciences of the United States of America·B P Sonnenblick

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