Parental genetic contributions in the AXB and BXA recombinant inbred mouse strains

Mammalian Genome : Official Journal of the International Mammalian Genome Society
D R Prows, Michelle L Horner

Abstract

Recombinant inbred (RI) strains are a valuable tool in mouse genetics to rapidly map the location of a new locus. Because RI strains have been typed for hundreds of genetic markers, the genotypes of individual strains within an RI set can be examined to identify specific strain(s) containing the desired region(s) of interest (e.g., one or more quantitative trait loci, QTLs) for subsequent phenotype testing. Specific RI strains might also be identified for use as progenitors in the construction of consomic (chromosome substitution strains or CSSs) or congenic lines or for use in the RI strain test (RIST). To quickly identify the genetic contributions of the parental A/J (A) and C57BL/6J (B) strains, we have generated chromosome maps for each commercially available AXB and BXA RI strain, in which the genetic loci are color-coded to signify the parent of origin. To further assist in strain selection for further breeding schemes, the percentages of A and B parental contributions were calculated, based on the total number of typed markers in the database for each strain. With these data, one can rapidly select the RI strain(s) carrying the desired donor and recipient strain region(s). Because points of recombination are known, start...Continue Reading

References

Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J D MarshallB Paigen
Aug 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M C BeckersP Gros
Nov 14, 1997·Immunology Today·E WakelandJ Longmate
Aug 26, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·S B SampsonB Paigen
Jan 9, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·K GillK Lake
Feb 27, 1999·International Archives of Allergy and Immunology·A DaserH Renz
Aug 13, 1999·The American Journal of Physiology·D R ProwsG D Leikauf
Sep 24, 1999·Biology of Reproduction·J L SpearowM Barkley
Mar 4, 2000·Nature Genetics·J H NadeauE S Lander
Aug 5, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·L D Dwyer-NieldA M Malkinson
May 16, 2001·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D M JuriloffC J Brown
Jun 21, 2001·American Journal of Respiratory Cell and Molecular Biology·D R Prows, G D Leikauf

❮ Previous
Next ❯

Citations

Sep 4, 2008·Radiation Research·Anne-Marie Lemay, Christina K Haston

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.