Parental history of lupus and rheumatoid arthritis and risk in offspring in a nationwide cohort study: does sex matter?

Annals of the Rheumatic Diseases
Emily C SomersHenrik Toft Sørensen

Abstract

To examine the familial risk of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), including juvenile rheumatoid/idiopathic arthritis (JRA), in a population-based setting; and to determine whether patterns of transmission differ according to the sex of the parent or offspring, in order to provide insight into the potential impact of X-chromosomal factors on sex disparities in these autoimmune diseases. A population-based cohort of parent-offspring triads from Denmark (1977-2010) was established. SLE and RA incidence rates among offspring were calculated, and Cox regression was performed to assess the sex-specific risk of disease in offspring according to maternal or paternal disease history. Among 3 513 817 parent-offspring triads, there were 1258 SLE cases among offspring (1095 female, 163 male) and 9118 cases of RA/JRA (6086 female, 3032 male). Among female offspring, SLE risk was nearly the same according to maternal (HR 14.1) or paternal (HR 14.5) history (p=NS); likewise among male offspring, risk according to maternal (HR 5.5) and paternal (no cases) history were similar (p=NS). For RA, all risk estimates were similar, regardless of the sex of the offspring or parent (HR 2.6-2.9; p=NS). The authors quantifi...Continue Reading

Citations

Apr 13, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sara K TedeschiKaren H Costenbader
Apr 22, 2016·Nature Reviews. Rheumatology·Thomhas FrisellJohan Askling
May 25, 2016·Annual Review of Genomics and Human Genetics·Chikashi TeraoPeter K Gregersen
Apr 26, 2014·Lupus·E C Somers, B C Richardson
Feb 11, 2015·Environmental Health Perspectives·Emily C SomersSung Kyun Park
Jul 11, 2013·Nature Reviews. Rheumatology·George K BertsiasDimitrios T Boumpas

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