Abstract
Parental history of type 2 diabetes (T2D) is associated with cardiometabolic risk. We aimed to investigate the associations of parental history of T2D with cardiometabolic biomarkers and to subsequently investigate to what extent these putative associations were explained by modifiable factors. Cross-sectionally, we analysed a random sample of 2001 participants without T2D (20-70 years) from the European Prospective Investigation into Cancer and Nutrition-Netherlands (EPIC-NL). Plasma levels of 12 biomarkers - total, HDL and LDL-cholesterol, triglycerides, HbA1c, gamma-glutamyltransferase (GGT), alanine aminotransferase (ALT), asparate aminotransferase (AST), albumin, uric acid, creatinine and high-sensitivity CRP (hs-CRP) - were assessed according to categories of parental history of T2D. In age and sex-adjusted analyses, offspring with parental history of T2D had significantly higher ALT [β = 0·074; 95% confidence interval (95%CI), 0·023-0·126] and AST levels (β = 0·033; 95%CI, 0·001 to 0·066) and a trend towards higher HbA1c (β = 0·011; 95%CI, -0·001 to 0·024) and GGT (β = 0·049; 95%CI, -0·015 to 0·112) levels. Adjustment for diet, smoking, alcohol intake, physical activity and educational level modestly attenuated the magni...Continue Reading
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