Abstract
Hypertrophic cardiomyopathy (HCM) is a common autosomal dominant condition with an increased risk of sudden cardiac death. Although clinical genetic testing can be used for confirmation of a clinical diagnosis as well as a predictive test, based on our clinical experience it is underutilized. Therefore, we developed and administered a questionnaire to assess potential determinants of parental interest in this testing. Of the 30 adult caregivers who participated, 80% had heard of genetic testing, whereas only 30% knew about genetic testing specifically for HCM. Once informed of the availability, 62% said they would consider testing in the future and 28% would consider it in the next year. Participants' younger age, higher education level, knowledge of carrier testing, and positive view of genetic testing were significantly associated with the participant considering HCM genetic testing for their child (p <or= 0.05). Based on a logistic regression model, age, education level, and knowing that HCM is an inherited disease were the best predictors of who would consider genetic testing. This study provides healthcare providers with a framework to understand caregivers' knowledge and views of genetic testing, which can be used to impr...Continue Reading
References
Sep 7, 1990·Cell·A A Geisterfer-LowranceJ G Seidman
Sep 7, 1990·Cell·G TanigawaC E Seidman
Aug 15, 1995·Circulation·B J MaronD E Bild
Apr 1, 1995·BMJ : British Medical Journal·M P RyanL Grigg
Feb 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A F PatenaudeF P Li
Apr 1, 1996·Journal of Medical Genetics·S MichieT Marteau
Nov 4, 2000·American Journal of Human Genetics·J W BrungerN H Robin
Mar 29, 2001·Journal of Molecular and Cellular Cardiology·A J Marian, R Roberts
Aug 3, 2001·European Heart Journal·S G PrioriD P Zipes
Feb 18, 2003·The American Journal of the Medical Sciences·Christine E McLarenUNKNOWN Hemochromatosis and Iron Overload Study Research Investigators
Mar 20, 2003·European Heart Journal·I M van LangenA A M Wilde
Oct 31, 2003·European Heart Journal·Barry J MaronUNKNOWN European Society of Cardiology Committee for Practice Guidelines
Nov 11, 2003·Journal of the American College of Cardiology·Barry J MaronUNKNOWN Committee for Practice Guidelines. European Society of Cardiology
Jun 11, 2005·Mayo Clinic Proceedings·Sara L Van DriestMichael J Ackerman
Sep 7, 2005·Clinical Genetics·I M van LangenA A M Wilde
Jun 21, 2006·Circulation·Carolyn Y Ho, Christine E Seidman
Aug 29, 2006·Circulation·Douglas P ZipesUNKNOWN Heart Rhythm Society
Sep 5, 2006·Journal of the American College of Cardiology·Douglas P ZipesUNKNOWN European Society of Cardiology Committee for Practice Guidelines
Sep 1, 2007·International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity·Mary E SegalPamela Sankar
Jan 30, 2008·Nature Clinical Practice. Cardiovascular Medicine·Andre KerenWilliam J McKenna
Feb 5, 2008·American Journal of Medical Genetics. Part a·Ellen M A SmetsAad Tibben
Feb 19, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Jodie InglesChristopher Semsarian
May 15, 2008·European Journal of Human Genetics : EJHG·Imke ChristiaansIrene M van Langen
Aug 8, 2008·Gynecologic Oncology·Robin A LacourKaren H Lu
Aug 23, 2008·Journal of Genetic Counseling·Janice AndersenEva Gjengedal
Nov 18, 2008·American Journal of Medical Genetics. Part a·Tineke M MeulenkampEllen M A Smets
Feb 13, 2009·American Journal of Medical Genetics. Part a·Wilma P van der RoestJ Peter van Tintelen
Mar 3, 2009·American Journal of Medical Genetics. Part a·Imke ChristiaansEllen M A Smets
Mar 4, 2009·Journal of Cardiac Failure·Ray E HershbergerUNKNOWN Heart Failure Society of America
Jun 18, 2009·American Journal of Medical Genetics. Part a·Imke ChristiaansEllen M A Smets
Citations
Oct 12, 2012·Journal of Genetic Counseling·Erin M MillerStephanie M Ware
Dec 4, 2013·The Nursing Clinics of North America·Kim Subasic
Jul 3, 2013·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Kim Subasic
Jan 9, 2015·Journal of Genetic Counseling·Amirah KhouzamJonathan A Bernstein
Sep 27, 2014·American Journal of Medical Genetics. Part a·Sara M Fitzgerald-ButtKim L McBride
Nov 15, 2011·Journal of the American College of Cardiology·Bernard J GershClyde W Yancy
Nov 15, 2011·Journal of the American College of Cardiology·Bernard J GershUNKNOWN American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Nov 19, 2011·The Journal of Thoracic and Cardiovascular Surgery·Bernard J GershClyde W Yancy
Nov 19, 2011·The Journal of Thoracic and Cardiovascular Surgery·Bernard J GershClyde W Yancy
Feb 9, 2017·Clinical Genetics·Q LimC E Wakefield
Nov 10, 2011·Circulation·Bernard J GershUNKNOWN Society of Thoracic Surgeons
Nov 10, 2011·Circulation·Bernard J GershUNKNOWN Society of Thoracic Surgeons
Oct 21, 2010·Annals of the New York Academy of Sciences·Kim L McBride, Vidu Garg
Jan 1, 2011·Current Opinion in Cardiology
Jun 4, 2011·Current Opinion in Anaesthesiology