PMID: 8953521Nov 1, 1996Paper

Parental MHC antigen sharing and pregnancy wastage in captive pigtailed macaques

Journal of Reproductive Immunology
L A KnappG P Sackett

Abstract

Among some human populations, immunogenetic similarity between mates is associated with increased risk of pregnancy loss. To investigate the relationship between histocompatibility and reproductive performance in non-human primates, 128 pigtailed macaque couples were classified as 'reproductively successful' or 'unsuccessful' according to previous breeding performance. These couples were arranged into 64 triads composed of individual females, and a 'successful' and 'unsuccessful' mate. Individuals were typed for class I MHC antigens using a microcytotoxicity technique and species-specific alloantisera. Matched-pair analysis revealed that significantly more 'unsuccessful' couples shared MnLA-A antigens than did the matched 'successful' couples. Conditional matched-pair logistic regression analysis further revealed that parental sharing of MnLA-A antigens is an even more significant predictor of pregnancy wastage than is advanced maternal age. In our study population, sharing of MnLA-A antigens predicted 72% of pregnancy loss among 'unsuccessful' couples (P < 0.009). Identification of histocompatibility-associated factors influencing pregnancy success could have profound clinical implications for chronic spontaneous abortion, int...Continue Reading

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Citations

Sep 14, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D W Zeh, J A Zeh
Oct 11, 2007·Journal of Molecular Evolution·Miguel AlcaideJuan J Negro
Aug 30, 2000·Molecular Ecology·T Tregenza, N Wedell
Jul 30, 2010·Proceedings. Biological Sciences·Jeremy Chase CrawfordChristine M Drea
Mar 13, 2014·Heredity·J B Wolf, Y Brandvain
Aug 19, 2008·The American Naturalist·Bethanne Zelano, Scott V Edwards
Sep 17, 2015·American Journal of Primatology·Sandiren NaikenNada Padayatchy
Mar 2, 2013·American Journal of Reproductive Immunology : AJRI·Elizabeth A Bonney
Nov 3, 2009·Journal of Evolutionary Biology·J B Wolf, R Hager
Sep 10, 2010·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Joanna M Setchell, Elise Huchard
Jul 1, 2000·Primates; Journal of Primatology·Shalini NairJeffrey Rogers
Nov 29, 2016·Canine Genetics and Epidemiology·Alina K NiskanenTanja Pyhäjärvi

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