Parental occupational exposures and risk of childhood cancer

Environmental Health Perspectives
J S Colt, Aaron Blair

Abstract

Occupational exposures of parents might be related to cancer in their offspring. Forty-eight published studies on this topic have reported relative risks for over 1000 specific occupation/cancer combinations. Virtually all of the studies employed the case-control design. Occupations and exposures of fathers were investigated much more frequently than those of the mother. Information about parental occupations was derived through interviews or from birth certificates and other administrative records. Specific exposures were typically estimated by industrial hygienists or were self-reported. The studies have several limitations related to the quality of the exposure assessment, small numbers of exposed cases, multiple comparisons, and possible bias toward the reporting of positive results. Despite these limitations, they provide evidence that certain parental exposures may be harmful to children and deserve further study. The strongest evidence is for childhood leukemia and paternal exposure to solvents, paints, and employment in motor vehicle-related occupations; and childhood nervous system cancers and paternal exposure to paints. To more clearly evaluate the importance of these and other exposures in future investigations, we ...Continue Reading

References

Dec 1, 1979·Journal of Epidemiology and Community Health·A F KantorJ T Flannery
Mar 1, 1979·American Journal of Epidemiology·E GoldM Szklo
Jun 1, 1976·British Journal of Preventive & Social Medicine·T HakulinenL Teppo
Mar 1, 1992·Cancer Causes & Control : CCC·L FeingoldE M John
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J H OlsenO M Jensen
Mar 23, 1991·BMJ : British Medical Journal·P A McKinneyL Parker
Mar 1, 1991·Journal of Epidemiology and Community Health·C Infante-RivardF Bolumar
Aug 1, 1990·Environmental Health Perspectives·D A Savitz, J H Chen
May 1, 1990·American Journal of Epidemiology·G R BuninA T Meadows
Jun 1, 1990·American Journal of Epidemiology·J R Wilkins, V D Hundley
Jan 1, 1988·American Journal of Industrial Medicine·J R Wilkins, R A Koutras
Feb 1, 1985·American Journal of Epidemiology·H A van Steensel-MollG E van Zanen
Jun 1, 1985·American Journal of Epidemiology·M R Spitz, C C Johnson
May 1, 1974·British Journal of Preventive & Social Medicine·J Fabia, T D Thuy
Mar 1, 1984·Journal of Epidemiology and Community Health·J R Wilkins, T H Sinks
Jun 1, 1984·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·J R Wilkins, T H Sinks
Dec 1, 1980·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·S L Kwa, L J Fine
Mar 1, 1981·Journal of Epidemiology and Community Health·K HemminkiH Vainio
Dec 1, 1981·Journal of Epidemiology and Community Health·B M SandersG J Draper
Mar 1, 1980·American Journal of Epidemiology·M ZackS Crowley
Oct 1, 1994·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·E L Baker
Aug 1, 1994·American Journal of Industrial Medicine·E F HeinemanA Blair
Feb 24, 1994·Nature·R DollS C Darby
Oct 16, 1993·BMJ : British Medical Journal·J R McLaughlinJ P Ashmore
Oct 1, 1996·Scandinavian Journal of Work, Environment & Health·J R Wilkins, L C Wellage
Apr 1, 1997·International Journal of Epidemiology·K H GelbergR Dubrow
Jul 1, 1998·Environmental Health Perspectives·S H Zahm, M H Ward

❮ Previous
Next ❯

Citations

Jan 24, 2009·Environmental Health Perspectives·Ghislaine ScéloPatricia A Buffler
Jun 25, 2014·British Journal of Cancer·S PetersL Fritschi
Apr 9, 2001·American Journal of Public Health·D M FreedmanM S Linet
Jan 14, 2003·Environmental Health Perspectives·Elizabeth M WardUNKNOWN National Occupational Research Agenda Team
Apr 5, 2003·Environmental Health Perspectives·Peggy ReynoldsDaniel F Smith
Nov 25, 2003·Occupational and Environmental Medicine·P A McKinneyUNKNOWN UK Childhood Cancer Study Investigators
Jun 3, 2005·Environmental Health Perspectives·Claire Infante-RivardLouise Nadon
Jul 17, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Maitreyi MazumdarUNKNOWN Kaohsiung Brain Tumor Research Group
Jan 2, 2010·International Journal of Health Geographics·Shihua Wen, Benjamin Kedem
Sep 13, 2011·International Journal of Environmental Research and Public Health·Glinda S CooperAmbuja S Bale
Sep 25, 2002·International Journal of Andrology·Ian D Morris
Oct 17, 2008·Radiation Protection Dosimetry·Patricia A McKinneyRichard G Feltbower
Aug 26, 2011·Cancer Causes & Control : CCC·Alison ReidLin Fritschi
Dec 26, 2015·International Journal of Environmental Research and Public Health·Laurens HolmesKirk Dabney
Nov 22, 2015·American Journal of Epidemiology·Frolayne M Carlos-WallaceCraig Steinmaus
Mar 8, 2016·Environmental Research·Javier García-PérezRebeca Ramis
Oct 10, 2007·Reproductive Toxicology·Tzu-I SungPau-Chung Chen
Jan 30, 2008·Basic & Clinical Pharmacology & Toxicology·Sylvaine Cordier
Mar 5, 2015·Journal of Exposure Science & Environmental Epidemiology·Todd P WhiteheadCatherine Metayer
Mar 25, 2015·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Tommaso FilippiniMarco Vinceti
Jun 18, 2016·BioMed Research International·Stephen J Genuis, Rebecca A Genuis
Apr 9, 2001·American Journal of Public Health·D A Savitz
Mar 9, 2017·Journal of Exposure Science & Environmental Epidemiology·Amanda E JanitzLogan Spector
Aug 19, 2007·Environmental Research·D BelpommeA J Sasco
Sep 9, 2004·Journal of Occupational and Environmental Medicine·Robbie AliDavid C Christiani
Oct 25, 2012·Environmental Health Perspectives·Jeniffer Dantas FerreiraUNKNOWN Brazilian Collaborative Study Group of Infant Acute Leukemia
Mar 27, 2001·Environmental Health Perspectives·M FeychtingA Ahlbom
Sep 13, 2012·British Journal of Cancer·T J KeeganM F G Murphy
Jun 28, 2018·International Journal of Public Health·Ming ChenGeliang Yang
May 21, 2019·British Journal of Cancer·Kathryn J BunchMichael F G Murphy
Sep 10, 2002·Journal of Toxicology. Clinical Toxicology·Philip J Landrigan, Anjali Garg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.