Parental occupational exposures and the risk of childhood sporadic retinoblastoma: a report from the Children's Oncology Group

Occupational and Environmental Medicine
Negar OmidakhshJulia E Heck

Abstract

We examined associations between parental occupational chemical exposures up to 10 years before conception and the risk of sporadic retinoblastoma among offspring. In our multicentre study on non-familial retinoblastoma, parents of 187 unilateral and 95 bilateral cases and 155 friend controls were interviewed by telephone. Exposure information was collected retroactively through a detailed occupational questionnaire that asked fathers to report every job held in the 10 years before conception, and mothers 1 month before and during the index pregnancy. An industrial hygienist reviewed all occupational data and assigned an overall exposure score to each job indicating the presence of nine hazardous agents. We estimated elevated ORs for unilateral and bilateral retinoblastoma among offspring of fathers who were exposed to polycyclic aromatic hydrocarbons or paints in the 10 years before conception. However, only for exposure to paints did confidence limits exclude the null for bilateral disease (OR: 8.76, 95% CI: 1.32 to 58.09). Maternal prenatal exposure to at least one of the nine agents was related to increased risk of unilateral disease in their children (OR: 5.25, 95% CI: 1.14 to 24.16). Fathers exposed to at least one of the...Continue Reading

References

Jan 1, 1992·Epidemiology·P Kristensen, A Andersen
Jun 1, 1992·Scandinavian Journal of Work, Environment & Health·J P BondeK S Hansen
Jan 1, 1991·American Journal of Industrial Medicine·L M O'LearyS London
Dec 15, 1990·American Journal of Ophthalmology·D J DerKinderenW Den Otter
Jan 1, 1986·American Journal of Industrial Medicine·B Knishkowy, E L Baker
Jan 3, 1996·International Journal of Cancer. Journal International Du Cancer·P KristensenL Sundheim
Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S C KasteC B Pratt
Mar 26, 1998·British Journal of Cancer·N T FearB Pannett
Dec 1, 2001·Journal of Occupational and Environmental Medicine·P Mutanen, K Hemminki
Feb 1, 2002·International Journal of Epidemiology·J D DockertyK J Bunch
Mar 26, 2003·Free Radical Research·Naoya NakaiShosuke Kawanishi
Sep 25, 2003·Occupational and Environmental Medicine·Y RodvallK Wiklund
Apr 6, 2004·Environmental Health Perspectives·Kori B FlowerDale P Sandler
Jul 13, 2005·Journal of Occupational and Environmental Medicine·Sai Yi PanUNKNOWN Canadian Cancer Registries Epidemiology Research Group
Sep 30, 2006·International Journal of Epidemiology·Benjamin H YipKamila Czene
Dec 22, 2007·Seminars in Ophthalmology·Yannek I LeidermanShizuo Mukai
Apr 30, 2008·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Hueiwang Anna Jeng, Liang Yu
Jul 16, 2008·The British Journal of Ophthalmology·E BroaddusA D Singh
Oct 23, 2008·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Ryan L WilliamsRobert I Krieger
Sep 23, 2009·Occupational and Environmental Medicine·A MacCarthyM F G Murphy
Jul 22, 2010·International Journal of Cancer. Journal International Du Cancer·Greta R BuninAnna T Meadows
Mar 10, 2011·International Journal of Cancer. Journal International Du Cancer·Mark P LittleMichael F G Murphy
Jul 31, 2012·Cancer Causes & Control : CCC·Julia E HeckBeate Ritz
Mar 19, 2013·Occupational and Environmental Medicine·Amir AbdolahiGreta R Bunin
Apr 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Leila SaremiZakiye Nadeali
May 23, 2014·Occupational and Environmental Medicine·Nicola CherryUNKNOWN participating centres of CHAPS-UK
Aug 9, 2016·International Journal of Ophthalmology·Yu-Qiong YangHong-Feng Yuan

❮ Previous
Next ❯

Citations

Aug 4, 2020·Pediatric Blood & Cancer·Omar ShakeelGreta R Bunin
Jun 28, 2018·International Journal of Public Health·Ming ChenGeliang Yang
Jun 3, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Philip J Lupo, Logan G Spector
Jan 5, 2021·Journal of Occupational and Environmental Medicine·Negar OmidakhshJulia E Heck
May 8, 2021·Cancer Reports·Manuela Orjuela-GrimmLourdes Cabrera-Muñoz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.