Using olfactory molecular specificity, we examined the inheritance of parental traumatic exposure, a phenomenon that has been frequently observed, but not understood. We subjected F0 mice to odor fear conditioning before conception and found that subsequently conceived F1 and F2 generations had an increased behavioral sensitivity to the F0-conditioned odor, but not to other odors. When an odor (acetophenone) that activates a known odorant receptor (Olfr151) was used to condition F0 mice, the behavioral sensitivity of the F1 and F2 generations to acetophenone was complemented by an enhanced neuroanatomical representation of the Olfr151 pathway. Bisulfite sequencing of sperm DNA from conditioned F0 males and F1 naive offspring revealed CpG hypomethylation in the Olfr151 gene. In addition, in vitro fertilization, F2 inheritance and cross-fostering revealed that these transgenerational effects are inherited via parental gametes. Our findings provide a framework for addressing how environmental information may be inherited transgenerationally at behavioral, neuroanatomical and epigenetic levels.
Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb
Cardiovascular and diabetes mortality determined by nutrition during parents' and grandparents' slow growth period
Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission
Exposure of mice to a predator odor increases acoustic startle but does not disrupt the rewarding properties of VTA intracranial self-stimulation
Duration of spermatogenesis in the mouse and timing of stages of the cycle of the seminiferous epithelium
Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model
Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood
Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health
Epigenetic programming by maternal behavior and pharmacological intervention. Nature versus nurture: let's call the whole thing off
Effects of in utero odorant exposure on neuroanatomical development of the olfactory bulb and odour preferences
Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals
Early prenatal stress epigenetically programs dysmasculinization in second-generation offspring via the paternal lineage
Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation
Gene bionetworks involved in the epigenetic transgenerational inheritance of altered mate preference: environmental epigenetics and evolutionary biology
Paternal alcohol exposure reduces alcohol drinking and increases behavioral sensitivity to alcohol selectively in male offspring
Pesticide methoxychlor promotes the epigenetic transgenerational inheritance of adult-onset disease through the female germline
Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress
Ingestional and transgenerational effects of the Fukushima nuclear accident on the pale grass blue butterfly
Regulatory RNAs and control of epigenetic mechanisms: expectations for cognition and cognitive dysfunction.
Roll over Weismann: extracellular vesicles in the transgenerational transmission of environmental effects
Transgenerational latent early-life associated regulation unites environment and genetics across generations
Maternal body mass index during early pregnancy, gestational weight gain, and risk of autism spectrum disorders: Results from a Swedish total population and discordant sibling study
De novo inbred heterozygous Zeb2/Sip1 mutant mice uniquely generated by germ-line conditional knockout exhibit craniofacial, callosal and behavioral defects associated with Mowat-Wilson syndrome
Placental, Matrilineal, and Epigenetic Mechanisms Promoting Environmentally Adaptive Development of the Mammalian Brain
Effect of high fat diet on paternal sperm histone distribution and male offspring liver gene expression
Hunting for Darwin's gemmules and Lamarck's fluid: transgenerational signaling and histone methylation
Transgenerational Inheritance of Paternal Neurobehavioral Phenotypes: Stress, Addiction, Ageing and Metabolism
Transgenerational influence of sensorimotor training on offspring behavior and its neural basis in Drosophila
NF-κB mediates Gadd45β expression and DNA demethylation in the hippocampus during fear memory formation
Potential Mechanisms Driving Population Variation in Spatial Memory and the Hippocampus in Food-caching Chickadees
Are single odorous components of a predator sufficient to elicit defensive behaviors in prey species?
Germ Cell Origins of Posttraumatic Stress Disorder Risk: The Transgenerational Impact of Parental Stress Experience
Age-related sperm DNA methylation changes are transmitted to offspring and associated with abnormal behavior and dysregulated gene expression
Psychophysiology and posttraumatic stress disorder symptom profile in pregnant African-American women with trauma exposure
Cross-generational impact of a male murine pheromone 2-sec-butyl-4,5- dihydrothiazole in female mice
Programming of stress-related behavior and epigenetic neural gene regulation in mice offspring through maternal exposure to predator odor
Quantifying polymorphism and divergence from epigenetic data: a framework for inferring the action of selection
Analytical strategies for the marble burying test: avoiding impossible predictions and invalid p-values
Friends with social benefits: host-microbe interactions as a driver of brain evolution and development?
Molecular mechanisms for the inheritance of acquired characteristics-exosomes, microRNA shuttling, fear and stress: Lamarck resurrected?
Beta and gamma oscillatory activities associated with olfactory memory tasks: different rhythms for different functional networks?
Hypomethylation of ERVs in the sperm of mice haploinsufficient for the histone methyltransferase Setdb1 correlates with a paternal effect on phenotype
The transgenerational transmission of childhood adversity: behavioral, cellular, and epigenetic correlates
Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor
The Epigenetic Consequences of Paternal Exposure to Environmental Contaminants and Reproductive Toxicants
Ancestral exposure to stress epigenetically programs preterm birth risk and adverse maternal and newborn outcomes
Short-term exposure to predation affects body elemental composition, climbing speed and survival ability in Drosophila melanogaster
Trans-generational desensitization and within-generational resensitization of a sucrose-best neuron in the polyphagous herbivore Helicoverpa armigera (Lepidoptera: Noctuidae)
Transgenerational transmission of a stress-coping phenotype programmed by early-life stress in the Japanese quail
Treating Generational Stress: Effect of Paternal Stress on Development of Memory and Extinction in Offspring Is Reversed by Probiotic Treatment
Paternal preconception alcohol exposure imparts intergenerational alcohol-related behaviors to male offspring on a pure C57BL/6J background
Epigenetic modifications and reprogramming in paternal pronucleus: sperm, preimplantation embryo, and beyond
Effects of mothers' and fathers' experience with predation risk on the behavioral development of their offspring in threespined sticklebacks
The neurobiological effects of stress as contributors to psychiatric disorders: focus on epigenetics
Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health
Lamarck rises from his grave: parental environment-induced epigenetic inheritance in model organisms and humans
Environmental stresses induce transgenerationally inheritable survival advantages via germline-to-soma communication in Caenorhabditis elegans
A neutrality test for detecting selection on DNA methylation using single methylation polymorphism frequency spectrum
Regulation and function of MeCP2 Ser421 phosphorylation in U50488-induced conditioned place aversion in mice
Paternal bisphenol a diet changes prefrontal cortex proteome and provokes behavioral dysfunction in male offspring
C. elegans SUP-46, an HNRNPM family RNA-binding protein that prevents paternally-mediated epigenetic sterility
Evidence from clinical and animal model studies of the long-term and transgenerational impact of stress on DNA methylation
Investigation into the role of the germline epigenome in the transmission of glucocorticoid-programmed effects across generations
Effects of Post-Weaning Chronic Stress on Nociception, Spinal Cord μ-Opioid, and α2-Adrenergic Receptors Expression in Rats and Their Offspring
Overexpression of Human-Derived DNMT3A Induced Intergenerational Inheritance of Active DNA Methylation Changes in Rat Sperm
DNA methylation-independent growth restriction and altered developmental programming in a mouse model of preconception male alcohol exposure
Identification and characterisation of microRNAs and Piwi-interacting RNAs in cockerels' spermatozoa by Solexa sequencing
Multigenerational transmission of liability to psychiatric illness in offspring of parents with bipolar disorder
Dexamethasone treatment alters insulin, leptin, and adiponectin levels in male mice as observed in DIO but does not lead to alterations of metabolic phenotypes in the offspring
The anthropometry of children and adolescents may be influenced by the prenatal smoking habits of their grandmothers: a longitudinal cohort study
Experimental evidence needed to demonstrate inter- and trans-generational effects of ancestral experiences in mammals
Increasing parental age at childbirth is associated with greater insulin sensitivity and more favorable metabolic profile in overweight adult male offspring
Effects of negative stressors on DNA methylation in the brain: implications for mood and anxiety disorders
Experience-sensitive epigenetic mechanisms, developmental plasticity, and the biological embedding of chronic disease risk
Nicotine exposure of male mice produces behavioral impairment in multiple generations of descendants
Passing experiences on to future generations: endocrine disruptors and transgenerational inheritance of epimutations in brain and sperm
Paternal methyl donor deficient diets during development affect male offspring behavior and memory-related gene expression in mice
Preconception paternal alcohol exposure exerts sex-specific effects on offspring growth and long-term metabolic programming
Endurance training remodels sperm-borne small RNA expression and methylation at neurological gene hotspots
Maternal witness to intimate partner violence during childhood and prenatal family functioning alter newborn cortisol reactivity
Research Review: Intergenerational transmission of disadvantage: epigenetics and parents' childhoods as the first exposure
Transgenerational epigenetic influences of paternal environmental exposures on brain function and predisposition to psychiatric disorders
Methylation of exons 1D, 1F, and 1H of the glucocorticoid receptor gene promoter and exposure to adversity in preschool-aged children
Intergenerational Effects of Alcohol: A Review of Paternal Preconception Ethanol Exposure Studies and Epigenetic Mechanisms in the Male Germline
Experience-based modulation of behavioural responses to plant volatiles and other sensory cues in insect herbivores
Overweight and CpG methylation of the Pomc promoter in offspring of high-fat-diet-fed dams are not "reprogrammed" by regular chow diet in rats
Is the growth of the child of a smoking mother influenced by the father's prenatal exposure to tobacco? A hypothesis generating longitudinal study
Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research
Intergenerational transmission of emotional trauma through amygdala-dependent mother-to-infant transfer of specific fear
Evidence from pyrosequencing indicates that natural variation in animal personality is associated with DRD4 DNA methylation
Developmental disruption of amygdala transcriptome and socioemotional behavior in rats exposed to valproic acid prenatally
Paternal nicotine exposure defines different behavior in subsequent generation via hyper-methylation of mmu-miR-15b
Transgenerational inheritance of learned preferences for novel host plant odors in Bicyclus anynana butterflies
The effects of childhood maltreatment on epigenetic regulation of stress-response associated genes: an intergenerational approach
Association of Periconception Paternal Body Mass Index With Persistent Changes in DNA Methylation of Offspring in Childhood
Transitions in paternal social status predict patterns of offspring growth and metabolic transcription
Does epigenetic 'memory' of early-life stress predispose to chronic pain in later life? A potential role for the stress regulator FKBP5
Germline epigenetic inheritance: Challenges and opportunities for linking human paternal experience with offspring biology and health
Heritable DNA Methylation in CD4+ Cells among Complex Families Displays Genetic and Non-Genetic Effects
Activity strengths of cortical glutamatergic and GABAergic neurons are correlated with transgenerational inheritance of learning ability
A-to-I RNA editing in the rat brain is age-dependent, region-specific and sensitive to environmental stress across generations
Individuality and Transgenerational Inheritance of Social Dominance and Sex Pheromones in Isogenic Male Mice
Intergenerational Effect of Maternal Childhood Maltreatment on Next Generation's Vulnerability to Psychopathology: A Systematic Review With Meta-Analysis
Transgenerational transmission of behavioral phenotypes produced by exposure of male mice to saccharin and nicotine
Perinatal nicotine exposure-induced transgenerational asthma: Effects of reexposure in F1 gestation.
The effect of odor enrichment on olfactory acuity: Olfactometric testing in mice using two mirror-molecular pairs
A historical and evolutionary perspective on the biological significance of circulating DNA and extracellular vesicles
"Racism as a public health issue" APS racism series: at the intersection of equity, science, and social justice
Fathers Matter: Why It's Time to Consider the Impact of Paternal Environmental Exposures on Children's Health
Reduced alcohol-seeking in male offspring of sires exposed to alcohol self-administration followed by punishment-imposed abstinence
The role of non-genetic inheritance in evolutionary rescue: epigenetic buffering, heritable bet hedging and epigenetic traps
Transgenerational inheritance of behavioral and metabolic effects of paternal exposure to traumatic stress in early postnatal life: evidence in the 4th generation
Paternal Preconception Every-Other-Day Ethanol Drinking Alters Behavior and Ethanol Consumption in Offspring
Transgenerational associations between maternal childhood stress exposure and profiles of infant emotional reactivity
Inter-generational resemblance of methylation levels at circadian genes and associations with phenology in the barn swallow
Stress Across Generations: DNA Methylation as a Potential Mechanism Underlying Intergenerational Effects of Stress in Both Post-traumatic Stress Disorder and Pre-clinical Predator Stress Rodent Models
The role of the genome in experience-dependent plasticity: Extending the analogy of the genomic action potential
A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans
Paternal Contributions to Offspring Health: Role of Sperm Small RNAs in Intergenerational Transmission of Epigenetic Information
Environmentally-Induced Transgenerational Epigenetic Inheritance: Implication of PIWI Interacting RNAs
Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment.
Paternal heat exposure causes DNA methylation and gene expression changes of Stat3 in Wild guinea pig sons
Epigenetic basis of sensitization to stress, affective episodes, and stimulants: implications for illness progression and prevention
Effects of Multi-Generational Stress Exposure and Offspring Environment on the Expression and Persistence of Transgenerational Effects in Arabidopsis thaliana
Paternal spatial training enhances offspring's cognitive performance and synaptic plasticity in wild-type but not improve memory deficit in Alzheimer's mice
Prenatal Glucocorticoid Exposure Modifies Endocrine Function and Behaviour for 3 Generations Following Maternal and Paternal Transmission
Effects of temperature and salinity stress on DNA methylation in a highly invasive marine invertebrate, the colonial ascidian Didemnum vexillum
The contribution of human sperm proteins to the development and epigenome of the preimplantation embryo
The Ever-Evolving Concept of the Gene: The Use of RNA/Protein Experimental Techniques to Understand Genome Functions
Ancestral Stress Alters Lifetime Mental Health Trajectories and Cortical Neuromorphology via Epigenetic Regulation
Transgenerational Inheritance of Environmentally Induced Epigenetic Alterations during Mammalian Development
Early-exposure to new sex pheromone blends alters mate preference in female butterflies and in their offspring
The impact of perinatal nicotine exposure on fetal lung development and subsequent respiratory morbidity
Lineage- and Sex-Dependent Behavioral and Biochemical Transgenerational Consequences of Developmental Exposure to Lead, Prenatal Stress, and Combined Lead and Prenatal Stress in Mice
The lasting impact of early-life adversity on individuals and their descendants: potential mechanisms and hope for intervention
Sperm microRNA Content Is Altered in a Mouse Model of Male Obesity, but the Same Suite of microRNAs Are Not Altered in Offspring's Sperm
Transgenerational inheritance of enhanced susceptibility to radiation-induced medulloblastoma in newborn Ptch1⁺/⁻ mice after paternal irradiation
Differential effects of developmental thermal plasticity across three generations of guppies (Poecilia reticulata): canalization and anticipatory matching
Preconception urinary phthalate concentrations and sperm DNA methylation profiles among men undergoing IVF treatment: a cross-sectional study
Medaka as a model for studying environmentally induced epigenetic transgenerational inheritance of phenotypes
Binge-Like Sucrose Self-Administration Experience Inhibits Cocaine and Sucrose Seeking Behavior in Offspring
Stress in the Educational System as a Potential Source of Epigenetic Influences on Children's Development and Behavior
Evolution without standing genetic variation: change in transgenerational plastic response under persistent predation pressure
Paternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells.
Transgenerational plasticity of inducible defences: Combined effects of grand-parental, parental and current environments
Masterpiece of epigenetic engineering - how Toxoplasma gondii reprogrammes host brains to change fear to sexual attraction
Stress and the Emerging Roles of Chromatin Remodeling in Signal Integration and Stable Transmission of Reversible Phenotypes
Oxidative Stress as Cause, Consequence, or Biomarker of Altered Female Reproduction and Development in the Space Environment
Early in life effects and heredity: reconciling neo-Darwinism with neo-Lamarckism under the banner of the inclusive evolutionary synthesis
More assortative mating in US compared to European parents and spouses of patients with bipolar disorder: implications for psychiatric illness in the offspring
Parental pre-conception stress status and risk for anxiety in rat offspring: specific and sex-dependent maternal and paternal effects
Paternal exposure to a common herbicide alters the behavior and serotonergic system of zebrafish offspring
The DNA methylome of human sperm is distinct from blood with little evidence for tissue-consistent obesity associations
Sex-specific plasticity across generations II: Grandpaternal effects are lineage specific and sex specific.
Neurophysiology of cognitive behavioural therapy, deep breathing and progressive muscle relaxation used in conjunction with ART treatments: a narrative review.
How do developmental and parental exposures to predation affect personality and immediate behavioural plasticity in the snail Physa acuta?
A legacy of fear: Physiological evidence for intergenerational effects of trauma exposure on fear and safety signal learning among African Americans.
Brief olfactory learning drives perceptive sensitivity in newborn rabbits: New insights in peripheral processing of odor mixtures and induction.
Paternal origins of obesity: Emerging evidence for incorporating epigenetic pathways into the social determinants of health framework.
A Neural System that Represents the Association of Odors with Rewarded Outcomes and Promotes Behavioral Engagement.
Repeated sampling facilitates within- and between-subject modeling of the human sperm transcriptome to identify dynamic and stress-responsive sncRNAs.
Pre-reproductive stress in adolescent female rats alters oocyte microRNA expression and offspring phenotypes: pharmacological interventions and putative mechanisms.
Heart rate variability in Konik and purebred Arabian horses in response to different predator vocalisations.
Paternal exposure to a common pharmaceutical (Ritalin) has transgenerational effects on the behaviour of Trinidadian guppies.
The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention.
Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C. elegans.
Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in humans
Causal role for sleep-dependent reactivation of learning-activated sensory ensembles for fear memory consolidation.
Epigenetics of the developing and aging brain: Mechanisms that regulate onset and outcomes of brain reorganization.
The "missing heritability"-Problem in psychiatry: Is the interaction of genetics, epigenetics and transposable elements a potential solution?
Age of onset of bipolar disorder: Combined effect of childhood adversity and familial loading of psychiatric disorders
Bioinformatic analysis revealing association of exosomal mRNAs and proteins in epigenetic inheritance
Acquisition of innate odor preference depends on spontaneous and experiential activities during critical period.
Life, death, and self: Fundamental questions of primitive cognition viewed through the lens of body plasticity and synthetic organisms
Correction to: 'How do developmental and parental exposures to predation affect personality and immediate behavioural plasticity in the snail Physa acuta?'
The developmental origins of chronic physical aggression: biological pathways triggered by early life adversity
The heart of the matter: Developing the whole child through community resources and caregiver relationships.
Modulation of olfactory signal detection in the olfactory epithelium: focus on the internal and external environment, and the emerging role of the immune system.
The "evolutionary field" hypothesis. Non-Mendelian transgenerational inheritance mediates diversification and evolution
Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.
Amygdala: Sensory Processes
Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.