PMID: 490581Aug 1, 1979Paper

Parental origin of triploidy and D and G trisomy in spontaneous abortions

Journal of Medical Genetics
B G Brennan, D H Carr

Abstract

A cytogenetic study of 15 triploid spontaneous abortuses, 12 trisomic abortuses, and their parents was carried out using the Q-banding technique. Polymorphic regions in abortus chromosomes were compared to corresponding regions of parental chromosomes to determine the origin of the extra chromosomes. Using marker chromosomes it was found that 7 triploids and only one trisomy were informative. Three triploids arose by failure to shed the second polar body during oogenesis. One triploid arose by dispermy. The other three triploids inherited an extra haploid set of chromosomes from the father, either by dispermy or by failure of the second meiotic division during spermatogenesis. The only informative trisomy, a trisomy 22, inherited the extra 22 from the mother. Chromosome polymorphisms are useful in determining the parental origin of extra chromosomes in certain cases.

References

Jan 1, 1975·Annual Review of Genetics·O J Miller, D A Miller
Mar 5, 1977·Lancet·D T Janerich, H I Jacobson
Jan 1, 1977·Cytogenetics and Cell Genetics·T Kajii, N Niikawa
Jul 1, 1976·Annals of Human Genetics·J A RobinsonR Hill
Apr 1, 1974·Journal of Reproduction and Fertility·N S Fechheimer, R A Beatty
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Oct 14, 1961·Lancet·I A UCHIDA, E J CURTIS

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Citations

Jan 1, 1984·Human Genetics·S Ishikiriyama, N Niikawa
Mar 1, 1987·Irish Journal of Medical Science·D Royston, J Bannigan
Apr 1, 1983·Mutation Research·I HansmannH D Probeck
Apr 1, 1982·Cancer Genetics and Cytogenetics·S D LawlerM W Evans
May 1, 1984·Annals of Human Genetics·T HassoldJ A Yamane
May 22, 1995·American Journal of Medical Genetics·P MinyJ Horst

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