Abstract
We combined the five chromosome 18 bipolar affective disorder data sets provided by GAW10, totaling 185 families with 3,394 individuals, and performed analysis of differential parental transmission and chromosome 18 marker allele sharing in families with transmission through fathers vs those through mothers. Results indicated a significant excess of maternal transmission of bipolar disorder. All pedigrees were then broken into nuclear families and affected sib-pair linkage analyses performed on the marker, D18S37. There was significant linkage in the data overall, as well as in each subgroup of paternal, maternal and unknown parental transmission nuclear families. There were no significant differences in identical-by-descent (IBD) scores among the three transmission subgroups. These findings support an excess of maternal transmission, and linkage between bipolar disorder and marker D18S37. However, our results do not support the previous suggestion that there are differences in chromosome 18 marker allele sharing depending on the transmitting parent.
References
Sep 1, 1981·Archives of General Psychiatry·J H Boyd, M M Weissman
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·W H BerrettiniE S Gershon
Apr 1, 1996·Nature Genetics·N B FreimerL A Sandkuijl
Apr 9, 1996·American Journal of Medical Genetics·E S GershonW H Berrettini
Dec 5, 1996·Nature·C O'Brien
Citations
Dec 15, 2010·Depression Research and Treatment·Christopher F Sharpley, Vicki Bitsika
Mar 18, 2009·PloS One·Brandi RollinsMarquis P Vawter
Jun 8, 2002·Annual Review of Neuroscience·W Maxwell CowanSteven E Hyman
Nov 6, 2003·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Wade Berrettini
Mar 29, 2007·Molecular Psychiatry·J G MulleA E Pulver
Jul 13, 2001·American Journal of Medical Genetics·V E MurphyP McKeon
Aug 31, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·O MukherjeeS Jain
Jul 27, 2001·Current Psychiatry Reports·E Bramon, P C Sham
Dec 18, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lynn M EvansJohn R Kelsoe
Jul 13, 2000·Molecular Psychiatry·K RojasJ Overhauser
Feb 13, 2002·Molecular Psychiatry·P BennettM Gill
Mar 28, 2003·Molecular Psychiatry·M G McInnisJ Raymond DePaulo
Aug 13, 2011·Current Psychiatry Reports·Shaza AlsabbanPeter McGuffin
Dec 20, 2000·American Journal of Medical Genetics·M Baron
Sep 22, 1999·American Journal of Medical Genetics·T BowenN Craddock
Feb 15, 2002·Bipolar Disorders·W H Berrettini
Jan 13, 2000·American Journal of Human Genetics·C FriddleD Botstein
Apr 25, 2000·Annual Review of Medicine·W H Berrettini