Parental transmission of risk for cannabis use disorders to offspring

Addiction
Derek B KostyPeter M Lewinsohn

Abstract

We investigated the risk of cannabis use disorder (CUD) among probands as a function of parental psychopathology and explored parent-offspring gender concordance as a mechanism of parental CUD transmission to offspring. Four waves of data collection from a longitudinal epidemiological study of psychopathology among a regionally representative sample. Participants were selected randomly from western Oregon, USA, and were initially assessed during mid-adolescence. The reference sample included 719 probands and their biological mothers and fathers. CUD episodes among probands were assessed with semistructured diagnostic interviews between mid-adolescence and young adulthood. Life-time psychiatric disorders among parents of probands were assessed when probands were approximately 24 years of age. There was an increased risk for CUD onset among probands with parental histories of CUD [hazard ratio (HR) = 1.93, 95% confidence interval (CI) = 1.30-2.88], hard drug use disorders (HR = 1.96, 95% CI = 1.32-2.90) or antisocial personality disorder (HR = 1.73, 95% CI = 1.06-2.82). A significant parent-offspring gender concordance effect indicated that females with a maternal CUD history were at higher risk for CUD onset compared with female...Continue Reading

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