Oct 3, 2014

Parente2: a fast and accurate method for detecting identity by descent

Genome Research
Jesse M RodriguezSerafim Batzoglou

Abstract

Identity-by-descent (IBD) inference is the problem of establishing a genetic connection between two individuals through a genomic segment that is inherited by both individuals from a recent common ancestor. IBD inference is an important preceding step in a variety of population genomic studies, ranging from demographic studies to linking genomic variation with phenotype and disease. The problem of accurate IBD detection has become increasingly challenging with the availability of large collections of human genotypes and genomes: Given a cohort's size, a quadratic number of pairwise genome comparisons must be performed. Therefore, computation time and the false discovery rate can also scale quadratically. To enable accurate and efficient large-scale IBD detection, we present Parente2, a novel method for detecting IBD segments. Parente2 is based on an embedded log-likelihood ratio and uses a model that accounts for linkage disequilibrium by explicitly modeling haplotype frequencies. Parente2 operates directly on genotype data without the need to phase data prior to IBD inference. We evaluate Parente2's performance through extensive simulations using real data, and we show that it provides substantially higher accuracy compared to...Continue Reading

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Mentioned in this Paper

Genome
Genetic Screening Method
Dysequilibrium Syndrome
Genomics
Linkage Disequilibrium
Two-Parameter Models
Datasets as Topic
Genetic Linkage
Genotype Determination
Phenotype Determination

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