Parenteral 17beta-estradiol decreases fasting blood glucose levels in non-obese mice with short-term ovariectomy

Life Sciences
Ju-Young KimSeong-Kyu Lee

Abstract

long-term ovariectomy-induced metabolic changes such as insulin resistance and glucose intolerance might be caused directly by estrogen deficiency and may occur partly as secondary effects of obesity arising due to the orexigenic effects of estrogen deficiency. Long-term estrogen treatment prevented those by exerting anorexigenic and metabolic actions in ovariectomized mice. However, the effect of short-term estrogen treatment on glucose metabolism in mice with short-term ovariectomy, during which ovariectomy-induced obesity does not develop, is not yet clear. The aim of this study was to evaluate the effect of short-term parenteral 17beta-estradiol treatment on glucose metabolism and blood glucose levels in mice at 2 weeks after ovariectomy, a time period during which ovariectomy-induced obesity does not develop. we examined the effect of three 17beta-estradiol injections on fasting blood glucose levels, insulin resistance, components of the insulin signaling pathway, AMPK activation, and the expression of genes related to glucose metabolism in liver, skeletal muscle, and white adipose tissues of non-obese C57BL/6N mice with short-term ovariectomy. three 17beta-estradiol injections decreased the fasting blood glucose levels, a...Continue Reading

References

Jul 1, 1997·Diabetes Care·S M HaffnerM P Stern
Feb 15, 2001·Frontiers in Bioscience : a Journal and Virtual Library·J W RyderJ R Zierath
May 1, 2001·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·C PecqueurD Ricquier
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Jul 18, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·Y-Q LiangY Ouchi
Sep 10, 2003·American Journal of Physiology. Endocrinology and Metabolism·Andreas Barthel, Dieter Schmoll
Feb 21, 2004·Science·Ronadip R BanerjeeMitchell A Lazar
Apr 3, 2004·Nature Reviews. Drug Discovery·Neil Ruderman, Marc Prentki
Jan 27, 2005·Diabetes & Metabolism·C PosticJ Girard
Sep 30, 2005·Diabetologia·I F Godsland
Aug 7, 2007·The Journal of Veterinary Medical Science·Atsuko SuzukiYasuhiko Ohta
Oct 13, 2007·The Journal of Steroid Biochemistry and Molecular Biology·G KoricanacE R Isenovic
Nov 4, 2008·Trends in Molecular Medicine·Ricardo LageMiguel López
Dec 9, 2008·Metabolism: Clinical and Experimental·Vitoon SaengsirisuwanChaivat Toskulkao
Mar 7, 2009·Biochemical and Biophysical Research Communications·Nicole H RogersAndrew S Greenberg
Mar 27, 2009·European Journal of Endocrinology·Kati PenttiSeppo Saarikoski
Apr 22, 2010·Family Practice·Alm Lagro-JanssenC van Weel

❮ Previous
Next ❯

Citations

Mar 6, 2013·Endocrine Reviews·Franck Mauvais-JarvisAndrea L Hevener
Jun 3, 2015·Molecular and Cellular Endocrinology·Andrea L HevenerFranck Mauvais-Jarvis
Sep 13, 2011·Cell Metabolism·Rodrigo P A Barros, Jan-Åke Gustafsson
May 5, 2017·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Britta H Riede-PultHeiko Pult
Jan 19, 2017·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Graeme YoungJames S Wolffsohn
Feb 14, 2020·Endocrinology·Andrea L HevenerZhenqi Zhou
Feb 15, 2017·Menopause : the Journal of the North American Menopause Society·Young-Min ParkRachael E Van Pelt
Feb 18, 2016·Medicine and Science in Sports and Exercise·Young-Min ParkVictoria J Vieira-Potter
Aug 19, 2015·Journal of Clinical Psychopharmacology·Núria Saigi-MorguiChin B Eap
Jan 25, 2014·Journal of Applied Physiology·J P A Cavalcanti-de-AlbuquerqueD P Carvalho
Sep 17, 2015·Bioscience Reports·Yulia LipovkaJohn P Konhilas
Sep 3, 2019·Journal of Nutritional Science and Vitaminology·Takumi Kanazawa
Mar 11, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alexandra Moreira-PaisRita Nogueira-Ferreira
Nov 30, 2016·Menopause : the Journal of the North American Menopause Society·Jugal Kishore DasMaria João Martins
Sep 19, 2019·The Journal of International Medical Research·Zheng-Ming YangHui-Min Tao
Mar 5, 2021·Vavilovskiĭ Zhurnal Genetiki I Selekt︠s︡ii·T V IakovlevaN M Bazhan
Oct 7, 2020·Trends in Molecular Medicine·Andrea L HevenerZhenqi Zhou
May 13, 2021·Indian Journal of Pharmacology·Seema Bansal, Kanwaljit Chopra
Jun 3, 2021·International Journal of Molecular Sciences·Agata Wawrzkiewicz-JałowieckaGraça Soveral

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.