PMID: 1080631Sep 1, 1975Paper

Parenteral aspirin produces and enhances gastric mucosal lesions and bleeding in rats

The American Journal of Digestive Diseases
J C MeeroffP H Guth

Abstract

The effect of parenteral sodium acetylsalicylate (Na ASA) on the development of gastric mucosal lesions and bleeding was studied in control rats and in rats subjected to cold-restraint stress. Although both doses of Na ASA studied, 15 and 60 mg/kg intraperitoneally, alone resulted in lesion formation, only with the larger dose did this reach the level of statistical significance. However both doses of Na ASA alone significantly increased blood loss as measured by a decrease in hematocrit value. The administration of Na ASA 15 MG/kg intraperitoneally to animals subjected to cold-restraint significantly increased blood loss, but not lesion formation, while the larger dose of Na ASA significantly increased both parameters. Thus parenteral aspirin not only can cause gastric mucosal damage and bleeding, but it can enhance lesion formation and blood loss produced by cold-restraint. Two mechanisms may be involved: a smaller dose of Na ASA significantly affecting hemostasis but a larger dose being required for gastric mucosal damage.

References

Mar 1, 1973·The American Journal of Digestive Diseases·A R Cooke
Mar 1, 1966·Clinical Pharmacology and Therapeutics·C DavisonR DeVine
Aug 9, 1969·British Medical Journal·A R Cooke, K Goulston
Oct 1, 1970·Journal of Pharmaceutical Sciences·J R Leonards, G Levy
Nov 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·A Gottschalk, R Menguy
Sep 1, 1968·The Journal of Clinical Investigation·H J WeissS Kochwa
Jul 1, 1967·Journal of Pharmaceutical Sciences·E MorrisJ E Christian
Nov 1, 1958·Lancet·A S ALVAREZ, W H SUMMERSKILL
Jun 1, 1964·Gut·A LYNCHG W MILTON
Mar 1, 1949·The American Journal of Digestive Diseases·J KATZ, R L DRYER
Apr 1, 1946·Annals of Internal Medicine·C M CARAVATI, E F COSGROVE

Citations

Sep 1, 1976·The American Journal of Digestive Diseases·D J St John, N D Yeomans
Oct 1, 1978·European Journal of Pharmacology·P A BrownJ Vernikos
Jan 1, 1979·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·K BruneA Schweitzer
Aug 1, 1980·Journal of Clinical Pathology·B C MorsonA Serck-Hanssen

Related Concepts

Metazoa
Micristin
Cold Temperature
Dose-Response Relationship, Drug
Structure of Pyloric Gland
Hematochezia
Injections, Intraperitoneal
Metabolic Stress Response
Rats, Laboratory

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.