PMID: 1080631Sep 1, 1975Paper

Parenteral aspirin produces and enhances gastric mucosal lesions and bleeding in rats

The American Journal of Digestive Diseases
J C MeeroffP H Guth


The effect of parenteral sodium acetylsalicylate (Na ASA) on the development of gastric mucosal lesions and bleeding was studied in control rats and in rats subjected to cold-restraint stress. Although both doses of Na ASA studied, 15 and 60 mg/kg intraperitoneally, alone resulted in lesion formation, only with the larger dose did this reach the level of statistical significance. However both doses of Na ASA alone significantly increased blood loss as measured by a decrease in hematocrit value. The administration of Na ASA 15 MG/kg intraperitoneally to animals subjected to cold-restraint significantly increased blood loss, but not lesion formation, while the larger dose of Na ASA significantly increased both parameters. Thus parenteral aspirin not only can cause gastric mucosal damage and bleeding, but it can enhance lesion formation and blood loss produced by cold-restraint. Two mechanisms may be involved: a smaller dose of Na ASA significantly affecting hemostasis but a larger dose being required for gastric mucosal damage.


Mar 1, 1973·The American Journal of Digestive Diseases·A R Cooke
Mar 1, 1966·Clinical Pharmacology and Therapeutics·C DavisonR DeVine
Aug 9, 1969·British Medical Journal·A R Cooke, K Goulston
Oct 1, 1970·Journal of Pharmaceutical Sciences·J R Leonards, G Levy
Nov 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·A Gottschalk, R Menguy
Sep 1, 1968·The Journal of Clinical Investigation·H J WeissS Kochwa
Jul 1, 1967·Journal of Pharmaceutical Sciences·E MorrisJ E Christian
Jun 1, 1964·Gut·A LYNCHG W MILTON
Mar 1, 1949·The American Journal of Digestive Diseases·J KATZ, R L DRYER
Apr 1, 1946·Annals of Internal Medicine·C M CARAVATI, E F COSGROVE


Sep 1, 1976·The American Journal of Digestive Diseases·D J St John, N D Yeomans
Oct 1, 1978·European Journal of Pharmacology·P A BrownJ Vernikos
Jan 1, 1979·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·K BruneA Schweitzer
Aug 1, 1980·Journal of Clinical Pathology·B C MorsonA Serck-Hanssen

Related Concepts

Cold Temperature
Dose-Response Relationship, Drug
Structure of Pyloric Gland
Injections, Intraperitoneal
Metabolic Stress Response
Rats, Laboratory

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