Parenteral immunization of fish, Labeo rohita with Poly D, L-lactide-co-glycolic acid (PLGA) encapsulated antigen microparticles promotes innate and adaptive immune responses

Fish & Shellfish Immunology
Truptimayee BeheraS K Sahoo

Abstract

Immunogenicity of different antigen preparations of outer membrane proteins (OMP) of Aeromonas hydrophila such as Poly d, l-lactide-co-glycolic acid (PLGA) microparticles, oil emulsion, neat OMP and bacterial whole cells were compared through intra-peritoneal injection in fish, Labeo rohita. Among these preparations, PLGA encapsulated antigen stimulated both innate and adaptive immune parameters and the immunogenicity exhibited by PLGA microparticles was significantly higher (p < 0.05) at both 21 and 42 days post-immunization suggesting that the above delivery system would be a novel antigen carrier for parenteral immunization in fish, Labeo rohita.

Citations

Mar 20, 2013·Fish & Shellfish Immunology·Carolina TafallaRoy A Dalmo
May 24, 2011·Nanoethics·Kåre Nolde NielsenAnne Ingeborg Myhr
Jan 26, 2016·International Journal of Biological Macromolecules·Aqdas NoreenMohammad Mujahid
Mar 19, 2011·Developmental and Comparative Immunology·Karen P Plant, Scott E Lapatra
Dec 26, 2013·Veterinary Immunology and Immunopathology·Fernando Jonas SutiliBernardo Baldisserotto
Aug 11, 2016·Anais Da Academia Brasileira De Ciências·Tatiana R PavanLuiz Carlos Kreutz
Aug 28, 2020·Frontiers in Immunology·Biswajit MaitiØystein Evensen
Jul 1, 2017·Comprehensive Reviews in Food Science and Food Safety·Catherine McLeodFrançoise S Le Guyader

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