Abstract
The aim of this study was to investigate factors associated with the development of parenteral nutrition-associated liver disease (PNALD) and to examine the clinicopathological relationship of PNALD in extremely low-birthweight infants (ELBWI). The subjects were 13 ELBWI who had received PN because of intestinal perforation or functional ileus between 2000 and 2013. We measured the serum levels of biochemical parameters, including aspartate aminotransferase, alanine aminotransferase, and direct bilirubin. Liver histopathology was examined in relation to outcome. The subjects were categorized into two groups on liver histopathology: F(+), development of hepatic fibrosis and necrosis with/without cholestasis; and F(-), no hepatic fibrosis. Of 13 ELBWI, five died of hepatic failure, five died of sepsis, and the other three were alive at the time of the study. Of the five infants who died of hepatic failure, two developed fulminant hepatitis without cholestasis, and the other three developed chronic cholestasis and finally hepatic failure. Postmortem histopathology in F(+) indicated not only massive hepatic necrosis, but also massive hepatic fibrosis. These histopathological findings explained the clinical presentation of portal hy...Continue Reading
References
Jun 1, 1990·Journal of Pediatric Surgery·A KubotaY Takagi
Nov 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·R A Drongowski, A G Coran
Jan 1, 1987·Gastroenterology·R T StankoS A Adibi
Jan 1, 1971·The Journal of Pediatrics·V H PedenM A Skelton
Apr 1, 1996·Journal of Pediatric Surgery·S V BeathI W Booth
Jan 23, 1998·Nutrition·D A Kelly
Aug 14, 1998·Journal of Pediatric Gastroenterology and Nutrition·J M SondheimerM Cadnapaphornchai
Jan 13, 2000·Pediatric Surgery International·Y TatekawaC Tsugawa
Aug 5, 2000·Journal of Pediatric Surgery·A KubotaA Okada
Sep 30, 2000·JPEN. Journal of Parenteral and Enteral Nutrition·K A KudskM K Hanna
Nov 18, 2000·Journal of Pediatric Surgery·D L CassD E Wesson
Feb 25, 2003·Pediatric Surgery International·Hiroomi OkuyamaMasafumi Kamiyama
Dec 1, 2004·JPEN. Journal of Parenteral and Enteral Nutrition·Laurence GentonKenneth A Kudsk
Jul 2, 2005·Journal of Pediatric Surgery·Patrick J JavidTom Jaksic
Aug 19, 2005·JPEN. Journal of Parenteral and Enteral Nutrition·Ariel U SpencerDaniel H Teitelbaum
Dec 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alan L BuchmanJonathan Fryer
Jul 20, 2006·World Journal of Surgery·Peter Mattei, John L Rombeau
Mar 9, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·R D ChristensenD K Lambert
Jul 27, 2007·Pediatric Surgery International·Akio KubotaMasahiro Nakayama
Dec 25, 2007·The Journal of Pediatrics·Daniel T Robinson, Richard A Ehrenkranz
Apr 9, 2008·Pediatrics·Viet HoangHouchang D Modanlou
Aug 8, 2009·Annals of Surgery·Mark PuderKathleen M Gura
Apr 14, 2011·Pediatrics International : Official Journal of the Japan Pediatric Society·Akio KubotaMasahiro Nakayama
Jan 17, 2012·Journal of Pediatric Surgery·Shawn J RangelUNKNOWN 2011 American Pediatric Surgical Association Outcomes and Clinical Trials Committee
Dec 18, 2012·Pediatrics International : Official Journal of the Japan Pediatric Society·Akio KubotaHiroyuki Kitajima
Nov 23, 2013·Journal of Hepatology·Dimitri Aristotle RaptisPierre-Alain Clavien