Parenteral nutrition in preterm neonates with and without carnitine supplementation

Acta Anaesthesiologica Scandinavica
L E LarssonG Cederblad

Abstract

The effects of carnitine supplementation on fat and glucose metabolism and carnitine balance were studied in 12 preterm neonates receiving full or partial parenteral nutrition (PN) for 5 to 21 days. The gestational age ranged from 27 to 32 weeks and the birth weight from 790 to 2090 g. The neonates were assigned at random to receive either L-carnitine 10 mg/kg (n = 6) or saline (n = 6). In the carnitine group, increased concentrations in plasma of total and free carnitine were observed. Less than 50% of the given dose was recovered in urine. In the placebo group no changes in the total plasma carnitine concentration were seen. In all neonates plasma triglycerides, free fatty acids, glycerol, alanine, 3-hydroxybutyrate (BOB), glucose and lactate were measured at predetermined intervals. The only significant difference between the groups was higher BOB-concentrations in the carnitine group 2 days after the start of parenteral nutrition. Elevated BOB concentrations are an indicator of improved fatty acid oxidation in the carnitine group. In this study, only a temporary effect of the carnitine supplementation was found.

References

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Citations

Jan 1, 1996·Life Sciences·S Krähenbühl
Apr 29, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·Sumati PandeNora V Esteban-Cruciani
Jun 1, 1996·Archives of Disease in Childhood·J H Walter
Mar 22, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Catherine M Crill, Richard A Helms
Feb 14, 2002·JPEN. Journal of Parenteral and Enteral Nutrition·UNKNOWN ASPEN Board of Directors and the Clinical Guidelines Task Force
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Oct 21, 2004·The Cochrane Database of Systematic Reviews·M KumarB Paes
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Aug 26, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Catherine M CrillRichard A Helms
Oct 18, 2000·The Cochrane Database of Systematic Reviews·P A Cairns, D J Stalker

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