PMID: 11922398Apr 2, 2002Paper

Parenteral troxerutin and carbazochrome combination in the treatment of post-hemorrhoidectomy status: a randomized, double-blind, placebo-controlled, phase IV study

Current Medical Research and Opinion
M BasileG S Gidaro

Abstract

Flavonoids, such as troxerutin, have been shown to be safe and effective agents for the treatment of chronic venous insufficiency. The fixed combination between troxerutin 150 mg and carbazochrome 1.5 mg (Fleboside ampoules) was previously shown to have a good efficacy and safety profile in non-surgical patients with acute uncomplicated hemorrhoids. The purpose of this randomized, double-blind, placebo-controlled study was to investigate the efficacy and tolerability of the active combination in the treatment of post-hemorrhoidectomy patients. 30 patients were randomized to receive one of two treatments: troxerutin 150 mg and carbazochrome 1.5 mg, or placebo, i.m. 3 ml ampoules twice a day for five consecutive days after the surgical procedure, starting from the day of surgery. Efficacy parameters were assessed as follows: at baseline (T1), after the first administration (T2; day of surgery), the second day after the surgical procedure (T3), and the fifth day after the surgical procedure (T4); hemorrhoidal symptoms based on a visual analogue scale (VAS): pain, discharge, bleeding, inflammation, and pruritus; analgesic intake, if any; time to restore a physiological defecation; edema evaluation (based on a four-point scale: 0 = ...Continue Reading

Citations

Apr 7, 2009·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Alper CelikSuna Omeroglu
Dec 31, 2009·Phytotherapy Research : PTR·Gianni BelcaroPeter Rohdewald
Jan 7, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Fatma I KhattabNermine S Ghoniem

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