PMID: 9660287Jul 11, 1998Paper

Parenteral vs oral antibiotics in the prevention of serious bacterial infections in children with Streptococcus pneumoniae occult bacteremia: a meta-analysis

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
S G RothrockR Bachur

Abstract

To determine whether parenteral antibiotics are superior to oral antibiotics in preventing serious bacterial infections in children with Streptococcus pneumoniae occult bacteremia. Using the MEDLINE database, the English language literature was searched for all publications concerning bacteremia, fever, or Streptococcus pneumoniae from 1966 to January 1, 1997. All nonduplicative studies with a series of children with S. pneumoniae occult bacteremia having both orally treated and parenterally treated groups were reviewed. Children were excluded from individual studies if at the time of their initial evaluation they were immunocompromised, had a serious bacterial infection, underwent a lumbar puncture, or did not receive antibiotics. Only 4 studies met study criteria. From these studies, 511 total cases of S. pneumoniae occult bacteremia were identified. Ten of 290 (3.4%) in the oral group and 5 of 221 (2.3%) in the parenteral antibiotic group developed serious bacterial infections (pooled p-value = 0.467, pooled OR = 1.48; 95% CI, 0.5-4.3). Two patients in the oral group (0.7%) and 2 patients in the parenteral group (0.9%) developed meningitis (pooled p-value = 0.699, pooled OR = 0.67; 95% CI, 0.1-5.1). The rates of serious bact...Continue Reading

References

Feb 1, 1978·Clinical Pediatrics·H J Hamrick, T F Murphy
Jan 1, 1991·The Journal of Pediatrics·S M DownsP A Margolis
May 1, 1991·Pediatrics·D M Jaffe, G R Fleisher
Nov 1, 1990·American Journal of Diseases of Children·E R WoodsP H Wise
Mar 1, 1985·Progress in Cardiovascular Diseases·S YusufP Sleight
Jan 1, 1989·The Pediatric Infectious Disease Journal·M A BaronD V Cicchetti
Jul 1, 1986·The Journal of Pediatrics·E D ShapiroD Chiponis
Nov 5, 1987·The New England Journal of Medicine·D M JaffeG Fleisher
Dec 1, 1987·Pediatric Emergency Care·L T YamamotoR A Dershewitz
Jun 21, 1973·The New England Journal of Medicine·J E McGowanM Finland
May 1, 1974·The Journal of Pediatrics·M G MyersD H Smith
Jan 1, 1970·American Journal of Diseases of Children·F J Heldrich
May 1, 1967·American Journal of Diseases of Children·M A Belsey
Sep 1, 1983·The Journal of Pediatrics·R A DershewitzD H Nadelman
Oct 29, 1981·The New England Journal of Medicine·D W TeeleJ O Klein
Jan 1, 1982·Annals of Emergency Medicine·N Rosenberg, S N Cohen
Jul 1, 1994·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·C M Olson
Dec 1, 1994·The Pediatric Infectious Disease Journal·R J LeggiadroF C Tenover
Mar 1, 1994·Annals of Emergency Medicine·R D CoxD J Woolard
Jan 1, 1994·Archives of Pediatrics & Adolescent Medicine·C M VadheimJ I Ward
Apr 1, 1994·The Journal of Pediatrics·S S Long
Jun 1, 1993·The Pediatric Infectious Disease Journal·J W BassJ M Vincent
Sep 1, 1993·The American Journal of Emergency Medicine·S Rosenzweig
Aug 1, 1993·Pediatric Annals·M B Harper, G R Fleisher
Jan 13, 1993·JAMA : the Journal of the American Medical Association·W G AdamsJ D Wenger
Jan 13, 1993·JAMA : the Journal of the American Medical Association·L E BroadhurstP W Kelley
Sep 1, 1995·The Pediatric Infectious Disease Journal·M B HarperG R Fleisher
Jul 1, 1997·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·B BullochT P Klassen
Feb 1, 1962·The Journal of Clinical Investigation·R G PETERSDORFM GARCIA

❮ Previous
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Citations

Jun 1, 2000·Indian Journal of Pediatrics·J G Ruiz, J M Lozano
Aug 7, 2003·The Journal of Emergency Medicine·Mardi SteerePhyllis H Stenklyft
Jan 12, 2005·Pediatric Emergency Care·Jonathan SingerJonathan Taylor
Mar 16, 2012·The Pediatric Infectious Disease Journal·Anne Vergison, Germaine Hanquet
Jun 10, 2010·Pediatric Emergency Care·Mark D Joffe, Elizabeth R Alpern
Dec 24, 1998·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·N Kuppermann
Apr 28, 2009·Infectious Disease Clinics of North America·Alexandros P GrammatikosMatthew E Falagas
Apr 1, 2006·Pediatric Clinics of North America·Paul Ishimine
Jan 13, 2009·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Matthew WilkinsonMatthew Smith
Jan 12, 2000·Pediatric Clinics of North America·N Kuppermann
Feb 10, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·UNKNOWN Japanese Association for Infectious Diseases/Japanese Society of Chemotherapy, The JAID/JSC Guide/Guidelines to Clinical ManToshihiko Mayumi
Nov 30, 2000·Annals of Emergency Medicine·L J Baraff

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