Parenthood and immunomodulation in patients with multiple sclerosis.

Journal of Neurology
Kerstin HellwigRalf Gold

Abstract

Little is known about the influence of immunomodulation on parenthood, in particular paternity in multiple sclerosis (MS). The objective was to determine whether there is an increased risk for pregnancies initiated by MS-parents under disease modifying therapies (DMT). We investigated the clinical outcome of pregnancies fathered by MS-patients under DMT by nationwide questionnaire and within our own outpatient clinic. Additionally, we compared the birth weight of children from MS-fathers exposed to DMT, MS-mothers without DMT, MS-mothers under interferon-beta (IFN beta) at the time of conception and healthy controls (HCs). DMT was reported for 32 paternities of 46 children; 30 under IFN beta, 12 under glatiramer acetate, 2 under natalizumab, 1 under methotrexate and 1 under combined azathioprine- and IFN beta-1b-treatment. Six (13%) pregnancies ended in early spontaneous abortions; of the 40 children of MS-fathers under DMT, 2 (5%) were preterm, 1 (2.5%) had a spinal lipoma and 3 (7.5%) had moderate hip dysplasia, of whom 2 were siblings whose mother had severe hip dysplasia. Mean birth weight of newborns from MS-fathers under DMT was not significantly reduced compared to HCs. Comparing birth weight of newborns of MS-mothers ve...Continue Reading

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Citations

Jun 3, 2014·BMC Neurology·Chiara PecoriUNKNOWN MS Study Group of the Italian Neurological Society
Aug 29, 2012·Journal of Neurology·Maria K Houtchens, Channa M Kolb
Jun 30, 2012·Medicina clínica·Carmen TurCristina Aguilera
Jul 31, 2012·Neurologic Clinics·P K Coyle
Jan 5, 2016·Journal of Neurology·Riley BoveD Rintell
Aug 10, 2016·Seminars in Immunopathology·Stefan M Gold, Rhonda R Voskuhl
Aug 23, 2016·Neurología : publicación oficial de la Sociedad Española de Neurología·M Mendibe BilbaoA Rodriguez-Antigüedad
Jan 22, 2014·Multiple Sclerosis : Clinical and Laboratory Research·David H MillerMaria Trojano
Jul 5, 2012·Multiple Sclerosis : Clinical and Laboratory Research·S AlwanA D Sadovnick
May 27, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Kerstin HellwigRalf Gold
Jan 13, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Sandra HerbstrittKerstin Hellwig
Mar 24, 2017·Expert Opinion on Drug Safety·Jan ThöneKerstin Hellwig
Jul 17, 2013·Therapeutic Advances in Neurological Disorders·Hanne F HarboMar Tintoré
Mar 29, 2019·The Medical Journal of Australia·Anneke Van Der WaltVilija Jokubaitis
Aug 1, 2013·Expert Review of Clinical Immunology·Angelo GhezziMaria P Amato
Jul 26, 2012·Clinical Obstetrics and Gynecology·Christy F Pearce, Wendy F Hansen
Sep 1, 2018·Neurology and Therapy·Yara Dadalti FragosoClaudia Cristina F Vasconcelos
May 25, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Gavin GiovannoniStuart Cook
Apr 6, 2021·Current Treatment Options in Neurology·Kristen M KryskoKerstin Hellwig

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