PMID: 8956978Nov 1, 1996Paper

Pargyline pretreatment prevents immunological changes induced by MPTP in mice

Immunopharmacology
K BieganowskaJ Korlak

Abstract

The relationship between the central dopaminergic and the immune system is poorly understood. Experimental work suggest that damage of the nigrostriatal system may influence immunity. Immunological abnormalities have been described in Parkinson's disease and in a mouse model of this disorder induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In this report, we present evidence that reduced numbers of L3T4 T cells in blood, and diminished primary antibody response to sheep erythrocytes in MPTP treated mice can be restored by pargyline pretreatment. Since pargyline prevents dopamine depletion in the striatum in MPTP treated animals, our data extend previous experimental observations and support a possible role for dopamine in immune regulation.

References

Mar 1, 1992·Neurochemistry International·R E Heikkila, P K Sonsalla
Dec 1, 1990·Journal of the Neurological Sciences·M AsanumaA Mori
Jan 1, 1990·Fundamental & Clinical Pharmacology·P J Neveu, M Le Moal
Apr 1, 1990·The International Journal of Neuroscience·B D Janković, D Marić
Jan 1, 1987·Journal of Neuroscience Research·R J CrossT L Roszman
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S P WilsonO H Viveros
Nov 1, 1994·Digestive Diseases and Sciences·Y Haskel, M Hanani
Jan 1, 1993·Journal of Neuroimmunology·K BieganowskaJ Korlak

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