Parietal cortex and movement. I. Movement selection and reaching

Experimental Brain Research
M F RushworthR E Passingham

Abstract

Recording studies in the parietal cortex have demonstrated single-unit activity in relation to sensory stimulation and during movement. We have performed three experiments to assess the effect of selective parietal lesions on sensory motor transformations. Animals were trained on two reaching tasks: reaching in the light to visual targets and reaching in the dark to targets defined by arm position. The third task assessed non-standard, non-spatial stimulus response mapping; in the conditional motor task animals were trained to either pull or turn a joystick on presentation of either a red or a blue square. We made two different lesions in the parietal cortex in two groups of monkeys. Three animals received bilateral lesions of areas 5, 7b and MIP, which have direct connections with the premotor and motor cortices. The three other animals subsequently received bilateral lesions in areas 7a, 7ab and LIP. Both groups were still able to select between movements arbitrarily associated with non-spatial cues in the conditional motor task. Removal of areas 7a, 7ab and LIP caused marked inaccuracy in reaching in the light to visual targets but had no effect on reaching in the dark. Removal of areas 5, 7b and MIP caused misreaching in th...Continue Reading

Citations

Nov 5, 2003·NeuroImage·M F S RushworthJ T Devlin
Apr 9, 1998·Neuropsychologia·M F RushworthR E Passingham
Mar 19, 2003·Behavioural Brain Research·P Paolo BattagliniMiran Skrap
Jul 17, 1999·Progress in Neurobiology·H E Savaki, Y Dalezios
Nov 2, 2001·Brain Research. Cognitive Brain Research·W FiasJ Lammertyn
Jul 26, 2003·NeuroImage·Georgia G Gregoriou, Helen E Savaki
Sep 16, 2011·Journal of Cognitive Neuroscience·Kenji Ogawa, Toshio Inui
Oct 1, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeffrey PadbergLeah Krubitzer
Mar 31, 2000·Trends in Cognitive Sciences·G Hickok, D Poeppel
Feb 24, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C D FrithD M Wolpert
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Andrea BrovelliSteven L Bressler
Mar 16, 2007·Social Cognitive and Affective Neuroscience·Tien-Wen LeeHugo D Critchley
Feb 6, 2008·Experimental Brain Research·Reza Shadmehr, John W Krakauer
Jun 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steve W C ChangLawrence H Snyder
Sep 19, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Thorsten TjardesHolger Baethis
Mar 2, 2010·Nature Neuroscience·Yuqing LiuLawrence H Snyder
Sep 17, 2010·Journal of Neurophysiology·Barbara HeiderRalph M Siegel
Apr 9, 2001·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·J L VelayS Benoit-Dubrocard
Feb 4, 2006·Neuropsychologia·M F S Rushworth, P C J Taylor
Sep 13, 2005·Brain and Cognition·Susanna Millar, Zainab Al-Attar
Feb 15, 2002·Brain : a Journal of Neurology·Alexandra Battaglia-Mayer, Roberto Caminiti
Apr 30, 2003·Neuron·Matthew I Leon, Michael N Shadlen
Feb 17, 2000·Neuron·M Riesenhuber, T Poggio
Feb 17, 2000·Neuron·C von der Malsburg
Feb 17, 2000·Neuron·A L Roskies
Jan 15, 2005·Current Biology : CB·Stephen R JacksonMasud Husain
Jul 10, 2012·Brain Research·H AkhlaghiG F Egan
Oct 21, 2015·The Journal of Comparative Neurology·Andrei Mayer de OliveiraJoão Guedes da Franca
Mar 3, 2017·Journal of Cognitive Neuroscience·Patricia F SayeghLauren E Sergio
May 15, 2004·Cerebral Cortex·Nicole WenderothStephan P Swinnen
Dec 2, 2017·Scientific Reports·Jakub Limanowski, Felix Blankenburg
May 23, 2001·Nature Neuroscience·M F RushworthV Walsh
Feb 18, 2005·Cerebral Cortex·Hans-Otto Karnath, Marie-Thérèse Perenin

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