PMID: 20644336Jul 21, 2010Paper

Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice: involvements of 5-HT1A receptor

Journal of Pharmacological Sciences
Eun-Joo ShinHyoung-Chun Kim

Abstract

Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT(1A) receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects phencyclidine-induced abnormal behaviors in mice. Phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin C. These effects were reversed by WAY 100635, a 5HT(1A)-receptor antagonist. Consistently, parishin C showed high affinity at 5-HT(1A) receptor as well as a 5-HT(1A)-agonist activity in a 8-OH-DPAT-stimulated [(35)S]GTP-gammaS binding assay. Our results suggest that the antipsychotic effects of parishin C require activation of 5-HT(1A) receptors.

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Citations

Jun 16, 2015·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Yi ZhengXi-Xi Zheng
Sep 30, 2015·Analytical and Bioanalytical Chemistry·Chunlan TangHongbin Xiao
Nov 19, 2015·Acta Pharmaceutica Sinica. B·Qinglan GuoJiangong Shi
Jul 6, 2016·Journal of Ethnopharmacology·Hong-Dan ZhanTing-Liang Jiang
Oct 22, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mariana MatiasGilberto Alves
Feb 1, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chunlan TangBocheng Yu
Feb 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Minhui HuMingqiu Shan
Sep 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yun LiZhi-Min Wang
Nov 18, 2019·Natural Products and Bioprospecting·Cheng-Bo XuJian-Gong Shi
Mar 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Limin LiGuixin Chou

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