PMID: 9663590Jul 15, 1998Paper

Parity, age at first birth and the risk of carcinoma in situ of the breast

International Journal of Cancer. Journal International Du Cancer
M LambeH O Adami

Abstract

Epidemiological studies of in situ breast cancer are sparse, and the role of reproductive history, an established risk modifier for invasive breast cancer, remains incompletely investigated. To examine possible associations with parity and age at first birth, we undertook a case-control study nested in a nationwide cohort of Swedish women. The reproductive history of 1,368 women aged 65 or younger with a diagnosis of carcinoma in situ of the breast were compared with that of 6,837 age-matched controls drawn randomly from a population-based Fertility Registry. Statistical analyses were performed by conditional logistic regression. Compared to nulliparous women, ever-parous women were at a reduced risk of carcinoma in situ of the breast. The risk decreased with number of live births, with the estimated risk reduction in the highest parity group (5+), being of the same magnitude as that reported for invasive breast cancer. By contrast, a positive association with increasing age at first birth was somewhat less pronounced than that observed previously in the same data set with respect to invasive breast cancer. Our findings indicate that parity affects the risk of invasive breast cancer and carcinoma in situ similarly, whereas the ...Continue Reading

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Citations

Jun 27, 2006·Breast Cancer Research : BCR·Jasmeet K GillLaurence N Kolonel
May 9, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lynette S PhillipsBeverly J Levine
Sep 27, 2015·Cancer Causes & Control : CCC·Katie M O'BrienClarice R Weinberg
Aug 5, 2000·Current Problems in Cancer·E Rakovitch
Aug 15, 2014·Journal of the National Cancer Institute·William F AndersonMark E Sherman
Dec 13, 2018·Cancer Causes & Control : CCC·Michelle L BagliaChristopher I Li
Nov 15, 2000·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·J A Alvarez-Riesgo
Dec 6, 2001·Journal of the National Cancer Institute·E B ClausD Carter
Jan 25, 2005·Journal of Women's Health·Patricia CaseDonna Spiegelman
Jun 17, 2004·Journal of the National Cancer Institute·Gregory D Leonard, Sandra M Swain
Apr 1, 2004·International Journal of Cancer. Journal International Du Cancer·Kathleen MeeskeLeslie Bernstein
Dec 2, 2005·Breast Cancer Research and Treatment·Bircan ErbasDorota Gertig
Oct 24, 2003·Breast Cancer Research and Treatment·Elizabeth B ClausDarryl Carter
Jul 13, 2013·Scientific Reports·Jinny K EunV K Gadi

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