PMID: 9532253Aug 1, 1997Paper

Parity among atopic and non-atopic mothers

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
L NilssonB Björkstén

Abstract

A temporary Th2 skewed immunity is essential for a successful outcome of pregnancy. It is also a hallmark of atopic disease. We recorded the number of siblings to 3667 children in relation to maternal atopy. In all, 65% of the allergic and 56% of the non-allergic mothers had more than one child (p < 0.001). These data support a hypothesis that the atopic genotype may be associated with an increased likelihood for a successful outcome of pregnancy and thus from an evolutionary point of view compensate for the less efficient host defence against microbial infections associated with this type of immunity.

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Citations

Jul 31, 2007·Advances in Therapy·H Levent YilmazRamazan Gunesacar
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·B Björkstén
Jul 13, 2012·Journal of Reproductive Immunology·Marie PerssonMaria C Jenmalm
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Mar 5, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T WestergaardM Melbye
Dec 17, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Wilfried Karmaus, Ihuoma Eneli
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