Parity and mortality in cases of childhood-onset diabetes mellitus

Diabetes/metabolism Research and Reviews
Lena SjöbergJanne Pitkäniemi

Abstract

This study aims to assess the association between parity and mortality in adults with childhood-onset type 1 diabetes (T1D) and their matched controls. Individual data (308 617 person-years) on mortality and the reproductive histories of a Finnish cohort of 2307 women and 2819 men with T1D, each with two matched controls, were obtained from the National Population Register. All persons with diabetes had been diagnosed with T1D in 1965-1979 at the age of 17 or under. All-cause mortality in people without offspring was significantly higher than that in people with children among both people with diabetes and non-diabetic control persons in both sexes (all p-values <0.01). In men with offspring, the decrease of mortality rate compared with men without offspring was less marked among those with diabetes (9% reduction in mortality hazard ratio (HR) with one offspring, 47% with two) than among those without diabetes (33% HR (p = 0.025) and 61% HR (p = 0.023) reduction, respectively). In women with offspring, the association between parity and mortality was independent of diabetes status. Having at least two offspring was associated with a decreased hazard of diabetes-related death regardless of sex; among women with diabetes, even ha...Continue Reading

References

Feb 1, 1996·Diabetic Medicine : a Journal of the British Diabetic Association·R KaajaK Teramo
Jul 2, 2003·Diabetes Care·Keiko AsaoUNKNOWN Diabetes Epidemiology Research International Mortality Study Group
Oct 26, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·O Vérier-MineJ H Fuller
Feb 9, 2006·Acta Oncologica·Halla Skuladottir, Jørgen H Olsen
Aug 17, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·UNKNOWN DIAMOND Project Group
Oct 13, 2006·Statistics in Medicine·H PutterR B Geskus
Nov 15, 2007·American Journal of Epidemiology·Emily Grundy, Øystein Kravdal
Mar 1, 2008·Acta Paediatrica·G DahlquistUNKNOWN Swedish Childhood Diabetes Study Group
Apr 30, 2009·Diabetes·Per-Henrik GroopUNKNOWN FinnDiane Study Group
Feb 16, 2010·American Heart Journal·Nisha I ParikhErik Ingelsson
Feb 27, 2010·Diabetes Care·Kustaa HietalaUNKNOWN FinnDiane Study Group
Nov 30, 2010·European Journal of Public Health·Akiko TamakoshiUNKNOWN JACC Study Group
Sep 10, 2011·BMJ : British Medical Journal·Valma HarjutsaloPer-Henrik Groop
Dec 12, 2012·Journal of Epidemiology and Community Health·Esben AgerboTrine Munk-Olsen
Jun 22, 2013·BMC Medical Research Methodology·Carolina Meier-Hirmer, Martin Schumacher
Jan 7, 2015·JAMA : the Journal of the American Medical Association·Shona J LivingstoneUNKNOWN Scottish Renal Registry

❮ Previous
Next ❯

Citations

Mar 11, 2018·Central European Journal of Public Health·Beáta GavurováTatiana Vagašová

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.