PMID: 9427432Jan 14, 1998Paper

Parity and other reproductive factors and risk of adenomatous polyps of the distal colorectum (United States)

Cancer Causes & Control : CCC
E A PlatzE Giovannucci

Abstract

Evidence for an effect of reproductive factors on colorectal carcinogenesis is inconsistent and little is known about their role in development of precursor adenomatous polyps. We evaluated the relation between reproductive factors and distal colorectal adenomas (n = 982) during 14 years of follow up of 26,983 participants in the Nurses' Health Study (United States). The women were free of diagnosed cancer or polyps in 1980, underwent endoscopy 1980-94, and had reported on their parity, oral contraceptive (OC) use, and ages at menarche, first term-pregnancy, and menopause. We calculated relative risks (RR) and 95 percent confidence intervals (CI) using multiple logistic regression. Women with higher parity had an increased risk of adenomas of the distal colorectum (P trend = 0.004; 6+ cf 0 parity: RR = 1.3, CI = 0.9-1.8) or distal colon (P trend = 0.002, RR = 1.7, CI = 1.2-2.6). This association was significantly stronger among women with a family history of colorectal cancer (P interaction = 0.03); comparing 6+ term-pregnancies with nulliparity, among those with a family history, the RR for distal colon adenoma was 3.2 (CI = 1.4-7.2), while among those without a family history, the RR was 1.3 (CI = 0.8-2.2). We observed no ass...Continue Reading

Citations

Aug 9, 2003·The American Journal of Gastroenterology·Laurent DukasEdward L Giovannucci
Apr 30, 2016·Cancer Causes & Control : CCC·Brittany M CharltonKarin B Michels
Feb 17, 2017·Cancer Causes & Control : CCC·Sheetal HardikarPolly A Newcomb
May 31, 2018·The Korean Journal of Internal Medicine·Nam Hee KimYoon Suk Jung
May 3, 2014·Epidemiology·Yunxia LuJesper Lagergren
Oct 23, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Munira AkhterUNKNOWN JPHC Study Group
Jul 28, 2016·American Journal of Public Health·Shilpa N BhupathirajuJoAnn E Manson
Feb 13, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J SongJ He

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