Dec 24, 2014

Parity is associated with a longer time to reach irreversible disability milestones in women with multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
S MaseraC Pozzilli

Abstract

Multiple sclerosis (MS) frequently affects women of childbearing age. While short-term effects of pregnancy on MS course are well-known, whether pregnancy may influence long-term disability progression is debated. A two-centre retrospective study to investigate long-term effect of pregnancy on disability was performed in a population of MS women. Survival analyses and multivariate Cox proportional regression models (including early predictors of MS severity and exposure to disease-modifying treatments) were performed to compare time to reach well-established disability milestones in nulliparous women and in those with pregnancies after MS onset ('parous'). Women with pregnancies before MS onset were excluded from analyses as they represent a heterogeneous group. Data about 445 women (261 nulliparous, 184 'parous') were analysed. A longer time to reach Expanded Disability Status Scale (EDSS) 4.0 and 6.0 was observed in parous women; Cox regression models revealed a lower risk for 'parous' than nulliparous women in reaching EDSS 4.0 and 6.0 (HR = 0.552, p = 0.008 and HR = 0.422, p = 0.012 respectively). Our findings suggest that pregnancy after MS onset is associated with a slower long-term disability progression. Whether this re...Continue Reading

  • References19
  • Citations8

Citations

Mentioned in this Paper

Survival Analysis
Disability Evaluation
Kurtzke Multiple Sclerosis Rating Scale
Late Onset Disorders
MS gene
Physically Challenged
Multiple Sclerosis, Acute Fulminating
Retrospective Studies
Multiple Sclerosis
Integumentary Scale

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