Dec 24, 2014

Parity is associated with a longer time to reach irreversible disability milestones in women with multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
S MaseraC Pozzilli


Multiple sclerosis (MS) frequently affects women of childbearing age. While short-term effects of pregnancy on MS course are well-known, whether pregnancy may influence long-term disability progression is debated. A two-centre retrospective study to investigate long-term effect of pregnancy on disability was performed in a population of MS women. Survival analyses and multivariate Cox proportional regression models (including early predictors of MS severity and exposure to disease-modifying treatments) were performed to compare time to reach well-established disability milestones in nulliparous women and in those with pregnancies after MS onset ('parous'). Women with pregnancies before MS onset were excluded from analyses as they represent a heterogeneous group. Data about 445 women (261 nulliparous, 184 'parous') were analysed. A longer time to reach Expanded Disability Status Scale (EDSS) 4.0 and 6.0 was observed in parous women; Cox regression models revealed a lower risk for 'parous' than nulliparous women in reaching EDSS 4.0 and 6.0 (HR = 0.552, p = 0.008 and HR = 0.422, p = 0.012 respectively). Our findings suggest that pregnancy after MS onset is associated with a slower long-term disability progression. Whether this re...Continue Reading

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Mentioned in this Paper

Survival Analysis
Disability Evaluation
Kurtzke Multiple Sclerosis Rating Scale
Late Onset Disorders
MS gene
Physically Challenged
Multiple Sclerosis, Acute Fulminating
Retrospective Studies
Multiple Sclerosis
Integumentary Scale

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