Parity reduces mammary repopulating activity but does not affect mammary stem cells defined as CD24 + CD29/CD49fhi in mice.

Breast Cancer Research and Treatment
Genevieve DallKara Britt

Abstract

Breast cancer (BCa) mortality is decreasing with early detection and improvement in therapies. The incidence of BCa, however, continues to increase, particularly estrogen-receptor-positive (ER +) subtypes. One of the greatest modifiers of ER + BCa risk is childbearing (parity), with BCa risk halved in young multiparous mothers. Despite convincing epidemiological data, the biology that underpins this protection remains unclear. Parity-induced protection has been postulated to be due to a decrease in mammary stem cells (MaSCs); however, reports to date have provided conflicting data. We have completed rigorous functional testing of repopulating activity in parous mice using unfractionated and MaSC (CD24midCD49fhi)-enriched populations. We also developed a novel serial transplant method to enable us to assess self-renewal of MaSC following pregnancy. Lastly, as each pregnancy confers additional BCa protection, we subjected mice to multiple rounds of pregnancy to assess whether additional pregnancies impact MaSC activity. Here, we report that while repopulating activity in the mammary gland is reduced by parity in the unfractionated gland, it is not due to a loss in the classically defined MaSC (CD24+CD49fhi) numbers or function. S...Continue Reading

References

Sep 1, 1977·Journal of the National Cancer Institute·H McGregorG W Beebe
Oct 15, 1990·International Journal of Cancer. Journal International Du Cancer·M EwertzH Tulinius
Apr 18, 1990·Journal of the National Cancer Institute·A G Glass, R N Hoover
Sep 6, 1989·Journal of the National Cancer Institute·D A HoffmanJ D Boice
Jan 1, 1982·Breast Cancer Research and Treatment·J RussoI H Russo
Feb 1, 1995·Japanese Journal of Cancer Research : Gann·K HiroseS Tokudome
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher I LiKathleen E Malone
Jan 15, 2005·Cancer Science·Koji TamakoshiUNKNOWN JACC Study Group
Jan 6, 2006·Nature·John StinglConnie J Eaves
Jan 7, 2006·Nature·Mark ShackletonJane E Visvader
Jan 19, 2006·Breast Cancer Research : BCR·Katherine E SleemanMatthew J Smalley
Mar 25, 2006·Nature Reviews. Cancer·Pepper Schedin
Dec 28, 2006·The Journal of Cell Biology·Katherine E SleemanMatthew J Smalley
Jan 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Wendy A WoodwardJeffrey M Rosen
Mar 3, 2007·Cancer Research·Piyush B GuptaCharlotte Kuperwasser
Oct 17, 2007·Environmental Health Perspectives·Barbara A CohnRobert I Sholtz
Nov 30, 2007·Endocrine-related Cancer·Kara BrittMatthew Smalley
Jun 4, 2011·Breast Cancer Research : BCR·François VaillantJane E Visvader
Oct 12, 2012·Breast Cancer Research and Treatment·J BigaardN Kroman
Oct 24, 2012·Breast Cancer Research : BCR·Mona ShehataJohn Stingl
Feb 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Alessandra InsingaPier Giuseppe Pelicci
Jan 28, 2014·Nature·Anne C RiosJane E Visvader
Sep 1, 2014·Nature Cell Biology·Michael D PraterJohn Stingl
Jan 27, 2015·Stem Cell Reports·Sung Jin HuhKornelia Polyak
Jun 13, 2015·Journal of the National Cancer Institute·Philip S RosenbergWilliam F Anderson
Feb 26, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Genevieve DallKara Britt
Jun 13, 2017·Frontiers in Oncology·Genevieve Victoria Dall, Kara Louise Britt

❮ Previous
Next ❯

Citations

Aug 28, 2021·Scientific Reports·Lone Rønnov-JessenOle William Petersen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Related Papers

The Journal of Steroid Biochemistry and Molecular Biology
Genevieve DallKara Britt
British Medical Journal
British Medical Journal
Cytometry. Part a : the Journal of the International Society for Analytical Cytology
Gat RaunerGerlinde R Van de Walle
© 2021 Meta ULC. All rights reserved