Parkin-independent mitophagy-FKBP8 takes the stage

EMBO Reports
Grace Gy Lim, Kah-Leong Lim

Abstract

Although the Parkin/PINK1 pathway has received considerable attention in recent years as a key regulator of mitophagy in mammals, it is important to recognize that multiple mitophagy receptors like BNIP3, NIX, and FUNDC1 exist that can promote the selective clearance of mitochondria in the absence of Parkin. In this issue, Bhujabal et al expand the repertoire of Parkin-independent mitophagy receptors to include the anti-apoptotic protein, FKBP8. The authors demonstrate that FKBP8 interacts preferentially with LC3A via its LIR motif to destroy damaged mitochondria. During the process, FKBP8 escapes from the destruction presumably to prevent apoptosis during mitophagy [1].

References

Jan 1, 1962·The Journal of Cell Biology·T P ASHFORD, K R PORTER
Dec 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·Rachel L SchweersPaul A Ney
Nov 26, 2008·The Journal of Cell Biology·Derek NarendraRichard J Youle
Dec 24, 2010·Nature Reviews. Molecular Cell Biology·Richard J Youle, Derek P Narendra
Jan 31, 2013·Nature Communications·Shotaro SaitaKeiichi I Nakayama
Nov 2, 2013·EMBO Reports·George F G AllenIan G Ganley
Apr 7, 2017·EMBO Reports·Zambarlal BhujabalTerje Johansen

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Citations

Aug 30, 2018·Nature Cell Biology·Konstantinos PalikarasNektarios Tavernarakis
Aug 17, 2019·Cells·David P DannheisigAstrid S Pfister
Jan 18, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xiao-Le WangYi Zhang
May 23, 2020·Current Neuropharmacology·Dmitrii M BelousovGjumrakch Aliev

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